PAKs, RAC/CDC42 (p21)-activated Kinases

PAKs, RAC/CDC42 (p21)-activated Kinases, 1st Edition

Towards the Cure of Cancer and Other PAK-dependent Diseases

PAKs, RAC/CDC42 (p21)-activated Kinases, 1st Edition,Hiroshi Maruta,ISBN9780124071988

H Maruta   





229 X 152

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds.

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Key Features

  • This publication will be the very first book ever published solely focused on PAK family kinases.
  • Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight.  
  • Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book.
  • This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.


This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.

This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins.


This book will be of interest to pharmaceutical scientists and other biomedical research scientists, clinical doctors and even patients who suffer from PAK-dependent diseases.

Information about this author is currently not available.

PAKs, RAC/CDC42 (p21)-activated Kinases, 1st Edition

List of Contributors

Introduction: Pushing the Boundary Toward Clinical Application: After 35 Years, PAK Research Comes of Age



1. Functional Maturation of PAKs from Unicellular to Multicellular Organisms


1.1 Introduction

1.2 MIHCKs/PAKs and Myosin I in Unicellular Acanthamoeba and Multicellular Dictyostelium

1.3 PAK Evolution Among Metazoans (Unicellular Versus Multicellular)

1.4 PIX in Fruit Fly Drosophila and Nematode C. elegans

1.5 FYN/ETK-Dependent Activation of PAK1

1.6 Evolution of Merlin, Nischarin, and LBK1 (PAK Inhibitors)

1.7 Concluding Remarks



2. Oncogenicity of PAKs and Their Substrates


2.1 Introduction

2.2 Loss of Contact Inhibition of Growth

2.3 Serum-Independent Growth

2.4 Anchorage-Independent Growth

2.5 Tumor-Induced Angiogenesis

2.6 Metastasis/Invasion

2.7 PAK1/PAK4-Dependent Solid Tumors

2.8 Oncogenic Targets of PAKs

2.9 Concluding Remarks



3. Natural or Synthetic Therapeutics That Block PAKs


3.1 Introduction

3.2 Synthetic Chemical Therapeutics

3.3 Natural PAK1 Blockers

3.4 PAK1 Blockers = AMPK Activators



4. PAK1–3 in Infectious Diseases

4.1 Malaria Infection

4.2 Enterobacterial Infection

4.3 Viral Infection



5. PAK1 in Brain Diseases or Disorders


5.1 Introduction

5.2 Tumorigenesis: NF, TSC, Retinoblastoma, and Gliomas

5.3 Epilepsy

5.4 Mental Retardation

5.5 Schizophrenia

5.6 Depression


6. PAK1 in Alzheimer’s and Huntington’s Diseases


6.1 Alzheimer’s Disease

6.2 Huntington’s Disease



7. PAK1 Controls the Lifespan


7.1 Introduction

7.2 Snell Dwarf Mice

7.3 RAC-Deficient Drosophila

7.4 PAK1 Blockers Extend the Lifespan of Tiny Animals

7.5 Crosstalk Between PI-3 kinase-PAK1 and TOR-S6K Signaling Pathways

7.6 The Nematode Caenorhabditis japonica as a Quicker Animal Model for Elixir Screening

7.7 Antiaging (Methuselah) Venture



8. 3D Structure and Physiological Regulation of PAKs

8.1 The PAK Family of Protein Kinases

8.2 Structural Mechanisms of PAK Regulation

8.3 Alternative Mechanisms Leading to PAK Activation

8.4 PAK Substrate Specificity and Downstream Signaling Events



Epilogue: “Lateral Thinking” Is the Key to a Great Leap in Biomedical Sciences


About the Authors

Quotes and reviews

"Here neurologists and other biomedical researchers explain in some detail how PAKs — particularly the oncogenic kinases PAK1 and PAK4 and their blockers — may control various aspects of life and health, and how mammalian PAKs have functionally evolved from their ancestral origins in unicellular organisms such as yeast and amoebas through a series of mutations over millions of years."--Reference and Research Book News, August 2013

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