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Mucosal Immunology
4th Edition - May 1, 2013
Editors: Jiri Mestecky, Warren Strober, Michael W. Russell, Hilde Cheroutre, Bart N. Lambrecht, Brian L Kelsall
Language: English
Hardback ISBN:9780124158474
9 7 8 - 0 - 1 2 - 4 1 5 8 4 7 - 4
eBook ISBN:9780124159754
9 7 8 - 0 - 1 2 - 4 1 5 9 7 5 - 4
Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectiou…Read more
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Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology.
This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency.
The most comprehensive text on mucosal immunology from internationally recognized experts in the field
Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases
Contains nine new chapters and an expanded appendix
In Memoriam
Preface to the First Edition
Preface to the Second Edition
Preface to the Third Edition
Preface to the Fourth Edition
Historical Aspects of Mucosal Immunology
Volume 1
Section A. Development and Organization of the Mucosal Immune System
Chapter 1. Overview: The Mucosal Immune System
Introduction
Mucosal Microbiota
Epithelial Cells as Essential Partners of the Mucosal Immune System
Antigen Uptake and Presentation in the Mucosal Immune System
Mucosal T Cells and Cell-Mediated Immunity
Mucosal Immunity and Homeostasis
Unique Features of Individual Components of the Mucosal Immune System and Their Integration
Global Impact of Mucosal Immunity in Vaccine Initiatives
The Future
Chapter 2. Development and Physiology of the Intestinal Mucosal Defense
Development of Mucosal Defense
The Development of Mucosal Immunity Continues during the Postnatal Period
Physiology of Mucosal Defense
Macromolecular Absorption
Physiologic Transport
Barriers Preventing Pathologic Transport
Chapter 3. Development of Gut-Associated Lymphoid Tissues
Introduction: Gut-Associated Lymphoid Tissues
Lymph Node and Peyer’s Patch Organogenesis
Solitary Intestinal Lymphoid Tissues
Chapter 4. Structure, Organization, and Development of the Mucosal Immune System of the Respiratory Tract
Introduction and Basic Anatomy of Lymphoid Tissues in the Respiratory Tract
Lymphoid Architecture of NALT
NALT Development
Antigen Acquisition in NALT
Immune Responses in NALT
NALT and Nasal Tolerance
Lymphoid Architecture of BALT
BALT Development
Antigen Acquisition in BALT
Immune Responses in BALT
BALT and Asthma
BALT and Chronic Obstructive Pulmonary Disease
BALT and Autoimmunity
BALT and Pulmonary Malignancy
Chapter 5. The Mucosal Microbiome: Imprinting the Immune System of the Intestinal Tract
Composition of the Intestinal Microbiome
Factors Influencing the Intestinal Microbiome
Sensing of the Microbiota by the Intestinal Immune System
Influence of the Microbiota on Immune Development and Function
Outlook
Chapter 6. The Microbiome at Other Mucosal Sites
Introduction
The Oral Microbiome
The Airway Microbiome
The Ocular Microbiome
The Genital Microbiome
Conclusions
Chapter 7. Endogenous Microbiota of the Genitourinary Tract
Introduction
Early Studies of VMB on the Basis of Culture and Microscopy
Molecular Microbiologic Investigations of VMB
Modulation of the Vaginal Mucosal Immune Response by VMB
Molecular Analysis of Male Genitourinary Tract Microbiota
Conclusions
Chapter 8. Gnotobiology and the Study of Complex Interactions between the Intestinal Microbiota, Probiotics, and the Host
Introduction: Microbiota and Microbiomes
Gnotobiology as a Tool: A Historical Perspective
Microbiota Perturbations in Human Disease
Mechanisms of Immunomodulation by Specific Members of the Intestinal Microbiota
Mechanisms of Immunomodulation by Probiotics
Conclusion
Chapter 9. Mucosal Immunity in Invertebrates
Introduction
Innate Immunity of Invertebrates
Conclusions
Chapter 10. Comparative Phylogeny of the Mucosa-Associated Lymphoid Tissue
Introduction
The Phylogeny of Immune Systems
General Characteristics of Mucosa-Associated Lymphoid Tissue in the Major Vertebrate Lineages
Conclusions
Chapter 11. Ontogeny of Mucosal Immunity and Aging
Ontogeny of Muscosal Immunology
Aging
Association of Ontogeny Profiles with Disease
Conclusions
Chapter 12. Epithelial Cells: Structure, Transport, and Barrier Function
Introduction
Structural Organization of the Intestine
Intestinal Epithelial Cell Types
Epithelial Polarity
The Paracellular Barrier
Transepithelial Transport
Molecular Architecture of Tight Junctions
Measuring Barrier Function
Ex vivo and In vitro Measures of Barrier Function
Barrier Function and Disease Pathogenesis
Models Linking Intestinal Barrier Loss to Experimental IBD
Intestinal Barrier Loss Promotes Compensatory Immunoregulatory Processes
Conclusion
Chapter 13. M Cells: Specialized Antigen Sampling Cells in the Follicle-Associated Epithelium
Fundamentals of Structure and Function of Intestinal Epithelium
Structure and Cellular Composition of Intestinal Absorptive Epithelium
Functions of Intestinal Absorptive Epithelium
The FAE of GALTs
Morphological Identification of M Cells
Markers for Identification of M Cells
Ontogeny of M Cells
M Cell Differentiation
Functions of Intestinal M Cells
M Cells in Other Mucosa-Associated Lymphoid Tissues
Conclusion
Chapter 14. Mucins and Mucus
Introduction
Biosynthesis and Structure of Mucins
Differentiation of Mucus Producing Cells and Regulation of Mucin Gene Expression
Functional Properties of Mucins
Subversion of Mucin Barriers by Mucosal Pathogens and Parasites
Mucins in Human Mucosal Inflammatory Diseases
Future Challenges
Chapter 15. Innate Humoral Defense Factors
Introduction
Pattern-Recognition Molecules
Lysozyme and HAMLET
Lactoferrin
Peroxidases
Other Factors
Chapter 16. Defensins in Enteric Mucosal Immunity
Antimicrobial Peptides and Innate Immunity
Cathelicidins
Defensins: Three Families of Cysteine-Rich AMPs
Mucosal Antimicrobial Proteins and Peptides
Mechanisms of α-Defensin Bactericidal Action
The Intestinal Epithelium
Paneth Cells
α-Defensin Biosynthesis
Paneth Cell α-Defensins
Paneth Cell α-Defensins and Innate Mucosal Immunity
Paneth Cell Defects and Mucosal Immunity
Chapter 17. Mucosal Immunoglobulins
Introduction
Igs of the External Secretions
IgA STRUCTURE AND ARRANGEMENT OF COMPONENT CHAINS
Biosynthesis and Assembly of IgA
IgA Metabolism
Chapter 18. Phylogeny and Comparative Physiology of Mucosal Immunoglobulins
Introduction
Phylogeny of Mucosal Ig’s in Jawed Vertebrates
Phylogeny of Polymeric Ig’s
Phylogeny of the Polymeric Ig Receptor, the Epithelial Transporter of Mucosal Ig’s
Comparative Physiology of Mucosal Ig’s
Conclusions
Chapter 19. Immunoglobulin Transport and Immunoglobulin Receptors
Introduction
Transport of Polymeric Ig by pIgR
Structure and Function of pIgR
Regulation of pIgR Expression
Organization and Regulation of the PIGR Gene
pIgR Trafficking and Signals
Regulation of pIgR Trafficking
Hepatobiliary Transport of IgA
Transport of IgG by the FcRn
Structure and Function of FcRn
Transcytosis of IgG by FcRn
Physiological Importance of FcRn-Mediated IgG Transcytosis
Exploitation of the FcRn–IgG Interaction for Therapeutic Purposes at Mucosal Surfaces
Systemic Functions of FcRn
Conclusions
Chapter 20. Fc Receptors in Mucosal Immunology
Introduction
Leukocyte IgA Receptors
FCα/μR
Nonleukocyte IgA Receptors
FCR-Mediated IgE Activity in Mucosal Secretions
Chapter 21. Biological Activities of IgA
Introduction
Biological Properties of IgA
IgA and Maintenance of Homeostasis
Chapter 22. Microbial Evasion of IgA Functions
Introduction
Specific IgA Proteases
Other Microbial Proteases with IgA-Cleaving Activity
Effect of Microbial Glycosidases on IgA
IgA-Binding Proteins
Conclusions
Chapter 23. The Regulation of IgA Production
Variable IgA Production in Mammals
Immune Geography and Lymphoid Structures Regulating IgA Production
T Cell-Dependent IgA Responses upon Colonization with a Microbiota
T Cell-Independent IgA Generation in Isolated Lymphoid Follicles
IgA Generation in Lamina Propria: Innate and Adaptive Crossroad
Heterogeneity of IgA Induction and Responses
Section B. Inductive and Effector Cells and Tissues of the Mucosal Immune System
Chapter 24. Overview: Inductive and Effector Cells and Tissues of the Mucosal Immune System
Chapter 25. Mucosal Dendritic Cells: Origins, Subsets, and Biology
Introduction
Origins of DCs
DCs Are Specialized Sentinels That Capture Antigens and Activate Naïve T Cells after Migrating to the Draining LNs
Dendritic Cells Can Directly Determine the Nature of the Ensuing Lymphocyte Response
Gastrointestinal Tract DCs
Respiratory Tract DCs
Genitourinary Tract DCs
General Conclusions
Chapter 26. Mucosal Macrophages in Defense and Regulation
Introduction
Ontogeny of Mucosal Macrophages
Phenotype of Resident Intestinal Macrophages
Defense and Regulatory Functions of Intestinal Macrophages
Role of Macrophages in Gastrointestinal Neoplasia
Intestinal Macrophages in Mucosal Infections
Chapter 27. Role of Epithelial Cells in Antigen Presentation
Introduction to Antigen Presentation and Function in Adaptive Immunity
Antigen Transport and Presentation by the Intestinal Epithelium
Conclusion
Chapter 28. Microbial Sensing and Regulation of Mucosal Immune Responses by Intestinal Epithelial Cells
Epithelial Cells Comprise Functionally Different Cell Types
Interaction of Epithelial Cells with the External World: Microbes
Interaction of Epithelial Cells with the Internal World: Immune Cells
Conclusions
Chapter 29. Epithelial Cell Regulation of Immune Responses in the Lung
Introduction
Asthma: A Th2 Cell-Mediated Disease with Alterations of ECs
Alterations to the Barrier Function of the Airway Epithelium Leads to Allergic Sensitization
Alterations in the Differentiation Program of Airway Epithelial Cells in Asthma
Epithelial Cells Sense Danger and Activate DCs
Epithelial Threshold for Allergen Recognition is Crucial in Causing Allergic Sensitization
An Interplay between Airway Epithelium and Dendritic Cells Controls Asthma Development
Defective Epithelial Cell Responses Contribute to Decreased Viral Clearance
Bronchial Epithelial Cells Produce Endogenous Danger Signals