Micheal J. Browne

Micheal J. Browne

Michael J. Browne graduated in Biochemistry for University College (London, UK) in 1973 and gained Ph.D. in molecular biology from the University of Glasgow in 1976. A keen desire to see rapid advances in molecular biology translated into therapeutic utility lead to work in the pharmaceutical industry, firstly with Beecham Pharmaceuticals (Great Burgh, Surrey,UK) and since 1989 with SmithKline Beecham (New Frontiers Science Park, Essex, UK). Though involved in numerous programs of research, cloning, expression and functionality of receptors, ranging from the single subunit G-protein linked receptors to the more complex cytokine receptors provided a key focus. He is interested not only in drug discovery by high throughput screens and rational medicinal chemical design but also via an understanding of the structure-function relationships of protein agonists and their interactions with the cognate receptor, which can then be exploited via protein engineering to design novel bioactive molecules. More recently the advent of high throughput cDNA sequencing and associated 'genomic strategies' has provided a springboard to discover yet more novel receptor systems of potential therapeutic benefit.

Affiliations and Expertise

SmithKline Beecham Pharmaceticals, Harlow, Essex, U.K.

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Micheal J. Browne

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