Handbook on the Toxicology of Metals

Handbook on the Toxicology of Metals, 4th Edition

Handbook on the Toxicology of Metals, 4th Edition,Gunnar Nordberg,Bruce Fowler,Monica Nordberg,ISBN9780444594532

Nordberg   &   Fowler   &   Nordberg   

Academic Press




276 X 216

This multidisciplinary resource integrates both human and environmental toxicology and is considered the foremost resource on metal toxicology available today!

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Key Features

  • Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems
  • Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health
  • Covers the toxicology of metallic nanomaterials in a new comprehensive chapter
  • Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste”
  • Other new chapters in the 4th edition include:  Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium


Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more.

Volume I covers “General Considerations” and Volume II is devoted to “Specific Metals.” A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.


The main audience includes toxicologists, physicians, pharmacologists and engineers in the fields of environmental and occupational health. Those working in governmental regulatory agencies, research labs, pharmaceutical and biotech companies and public health fields may also find this book valuable.

Gunnar Nordberg

Dr Gunnar F. Nordberg, MD, PhD, is an emeritus Professor at Umea University, Umea, Sweden, where he served as chairman of the Department of Environmental and Occupational Medicine for many years. He has also worked as a scientist at the International Agency for Research on Cancer, Lyon, France and as a Professor and chairman at the Department of Environmental Medicine, Odense University, Denmark. He has published more than 270 papers in Scientific Journals and International Handbooks. In addition, he edited or co-edited 23 Scientific Books and participated in International Task Groups evaluating Risks of Environmental Agents which resulted in 25 international books. Some of these publications resulted from his activities as a chairman of the Scientific Committee on the Toxicology of Metals, International Commission on Occupational Health. He is presently the Task Group Chairman of Cadmium Risk Assessment in the Toxicology and Risk Assessment Group of the International Union of Pure and Applied Chemistry. His Scientific Publications are mainly on Toxicology and Epidemiology of environmental agents, particularly metals. He has coordinated EU- projects on Environmental Epidemiology and Toxicology of Metals and participated as an active scientist in several such projects. He has been the principal investigator of many research projects funded by Swedish funding Agencies and is presently actively involved in such research. He is one of the editors of a Textbook in Swedish “Arbets- och Miljömedicin”, latest (3rd) Edition 2010. Chief Editor, Handbook on the Toxicology of Metals, 3rd Ed, published 2007 by Academic Press/Elsevier, new 4th edition publishing October 2014. He has extensive experience as an expert serving Swedish and International Authorities such as the Swedish National Board of Health (Socialstyrelsen), Japan Food Safety Agency, US Environmental Protection Agency, National Institute for Environmental Health Studies (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety; International Agency for Research on Cancer IARC, Lyon, France, World Health Organization, Europe/European Environment Agency, Copenhagen; European Food Safety Authority (EFSA), Parma, Italy.

Affiliations and Expertise

Umeå University, Department of Public Health and Clinical Medicine, Sweden

Bruce Fowler

Dr. Bruce A. Fowler Ph.D., A.T.S is currently a consultant and an Adjunct Professor at Emory University in Atlanta, Georgia, and a Presidents Professor of Biomedical Research at the University of Alaska- Fairbanks. He has previously held positions as a Senior Fellow/Expert Consultant at ICF International, Associate Director for Science in the Division of Toxicology and Environmental Medicine at ATSDR, Director of the System-wide Program in Toxicology at the University of Maryland and Senior Scientist at the NIEHS. He has been previously selected as a Fellow of the Japanese Society for the Promotion of Science (JSPS), Fulbright Scholar and Swedish Medical Research Council Visiting Professor at the Karolinska Institute in Stockholm Sweden. He has chaired and served on a number of national / international committees in the area of metal toxicology including those of the National Academies of Science, WHO, IARC, National Institutes of Health, and USEPA. Dr. Fowler is the author of over 260 research papers and book chapters dealing with molecular mechanisms of metal toxicity and molecular biomarkers for early detection of metal-induced cell injury. He has been the editor or co-editor of 7 books or monographs on metal toxicology, mechanisms of chemical - induced cell injury and computational toxicology. His current research is focused on computational toxicology and the application of molecular biomarkers for risk assessments of chemical mixtures involving metals, particularly in relation to binary semiconductor materials such as gallium arsenide, indium arsenide as well as lead, cadmium, and arsenic mixtures. He has received a number of awards for his research including a Society of Toxicology Colgate-Palmolive Visiting Professorship in In Vitro Toxicology to the University of Washington and CDC National Center for Environmental Health/ATSDR awards including the Honor Award for Excellence in Quantitative Sciences- Cadmium PbPK Modeling Group Award, NCEH/ATSDR Honor Award for Excellence in Emergency Response Deepwater Horizon Oil Spill Response Team (Domestic) Group Award. As a member of the elemental impurities panel, Dr. Fowler has also received the 2014 USP Award for an Innovative Response to Public Health Challenges (Group Award). He serves on the editorial boards of a number of scientific journals in toxicology and is currently an Associate Editor of Environmental Health Perspectives and Toxicology and Applied Pharmacology.

Affiliations and Expertise

Ph.D., A.T.S., Private Consulting Toxicologist, Adjunct Professor, Emory University, Rollins School of Public Health, and Presidents Professor of Biomedical Research, University of Alaska - Fairbanks

Monica Nordberg

Dr Monica Nordberg, Ph.D. is an emerita Professor at Karolinska Institutet (KI), Institute of Environmental Medicine, Stockholm, Sweden. She has served as chair of the Department of Environmental Hygiene, as member, Karolinska Institutet Study Program for Community Medicine, member of Education Policy Committee for Toxicology and Public Health, KI, Stockholm for many years. She has published 175 scientific articles, book chapters and review articles dealing with biochemical mechanisms and health effects related to exposure to metals mainly cadmium, lead and mercury and interaction with selenium. She is one of the editors of a Textbook in Swedish “Arbets- och Miljömedicin”, latest (3:rd) Edition 2010. Monica Nordberg is a co- editor and author, of the Handbook on the Toxicology of Metals 3rd edition, Academic Press/Elsevier, 2007 and, for the new 4th edition 2015. This work is within the framework of Scientific Committee on the Toxicology of Metals under International Commission on Occupational Health (SCTM/ICOH) which she served as secretary, chair and presently as former chair. She served as titular member of the Chemistry and Human Health of International Union of Pure and Applied Chemistry issuing recommendations regarding definitions and concepts. She was the Swedish representative in the Management Committee of COST Action, member EU Strategy Environment and Health, SCALE, Technical Working Group Indicators and Priority Diseases. She has experience as an expert serving Japan Food Safety Agency, US Environmental Protection Agency, National Institute for Environmental Health Studies (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety. Monica Nordberg is a full member of different societies such as Society of Toxicology, USA.

Affiliations and Expertise

PhD, Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden

Handbook on the Toxicology of Metals, 4th Edition

Chapter 1. Toxicology of Metals-Overview, Definitions, Concepts and Trends
Chapter 2. General Chemistry, Sampling, Analytical Methods and Speciation
Chapter 3. Routes of Exposure, Dose and Toxicokinetics of Metals
Chapter 4. Toxicity of Metal and Metal Oxide Nanoparticles
Chapter 5. Toxicity of Metals Released from Implanted Medical Devices
Chapter 6. Toxic Metals in Food
Chapter 7. Exposure Assessment, forward and reverse dosimetry
Chapter 8. Biological Monitoring and Biomarkers
Chapter 9. Selected Molecular Mechanisms of Metal Toxicity and Carcinogenicity
Chapter 10. General Considerations of Dose-effect and Dose-response Relationships
Chapter 11. Interactions and Mixtures in Metal Toxicology
Chapter 12. Gene-environment interactions
Chapter 13. Epidemiological approaches to metal toxicology
Chapter 14. Essential Metals: Assessing Risks from Deficiency and Toxicity
Chapter 15. Neurotoxicology of Metals
Chapter 16. Cardiovascular disease
Chapter 17. Renal effects of Exposure to Metals
Chapter 18. Carcinogenicity of Metal Compounds
Chapter 19. Immunotoxicology of metals
Chapter 20. Effects of Metallic Elements on Reproduction and Development
Chapter 21. Ecotoxicology of Metals- Sources, Transport and Effects in the Ecosystem
Chapter 22. Risk assessment
Chapter 23. Diagnosis and Treatment of Metal Poisoning-general Aspects
Chapter 24. Principles for Prevention of the Toxic Effects of Metals
Chapter 25. Metal toxicology in developing countries
Chapter 26. Aluminum
Chapter 27. Antimony
Chapter 28. Arsenic
Chapter 29. Barium
Chapter 30. Beryllium
Chapter 31. Bismuth
Chapter 32.  Cadmium
Chapter 33. Chromium
Chapter 34. Cobalt
Chapter 35. Copper
Chapter 36. Gallium and Semiconductor Compounds
Chapter 37. Germanium
Chapter 38. Gold and Gold Mining
Chapter 39. Indium
Chapter 40. Iridium
Chapter 41. Iron
Chapter 42. Lanthanum
Chapter 43. Lead
Chapter 44. Lithium
Chapter 45. Manganese
Chapter 46. Mercury
Chapter 47. Molybdenum
Chapter 48. Nickel
Chapter 49. Palladium
Chapter 50. Platinum
Chapter 51. Rhodium
Chapter 52. Selenium
Chapter 53. Silver
Chapter 54. Tellurium
Chapter 55. Thallium
Chapter 56. Tin
Chapter 57. Titanium
Chapter 58. Tungsten
Chapter 59. Uranium
Chapter 60. Vanadium
Chapter 61. Zinc

Quotes and reviews

"The handbook is a weighty collection of 47 essays in the fields of toxicology and ecology of metals, reflecting a wide range of specialist knowledge from authors of several parts of theworld. It promotes awareness of health threats of the general public as well as of professionals in various occupations, constituting a valuable reference source for physicians, toxicologists, scientists in several areas, legislators and managers of environmental and occupational safety organizations. The scope of the handbook is wide and multidisciplinary, integrating human and environmental ecology. It is desireable that the handbook will find its way to many bookshelves at hospitals, industrial and governmental libraries and several research institutes in every part of the world."--Science of The Total Environment
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