Handbook of Nanosafety

Handbook of Nanosafety, 1st Edition

Measurement, Exposure and Toxicology

Handbook of Nanosafety, 1st Edition,Ulla Vogel,Kai Savolainen,Qinglan Wu,Martie van Tongeren,Derk Brouwer,Markus Berges,ISBN9780124166042

Vogel   &   Savolainen   &   Wu   &   van Tongeren   &   Brouwer   &   Berges   

Academic Press




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A comprehensive and practical reference for occupational nanotoxicology and nanosafety

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Key Features

  • Multi-authored book, written by leading researchers in the field of nanotoxicology and nanosafety
  • Features state-of-the-art physical and chemical characterization of engineered nanomaterials (ENM)
  • Develops strategies for exposure assessment, risk assessment and risk management
  • Includes practical case studies and exposure scenarios to demonstrate how you can safely use ENM in the workplace


Handbook of Nanosafety: Measurement, Exposure and Toxicology, written by leading international experts in nanosafety, provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace.

Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, Handbook of Nanosafety demonstrates techniques to assess exposure and risks and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM.

Based on outcomes from the NANODEVICE initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment.


Toxicologists and scientists who work with ENM and aerosols. Occupational Toxicologists. Regulatory Toxicologists. Risk Assessors. Nanosafety managers. Industrial Hygienists

Ulla Vogel

Affiliations and Expertise

National Research Centre for the Working Environment, Copenhagen, Denmark

Kai Savolainen

Kai Savolainen is Research Professor, Nanosafety Research, at the Finnish Institute of Occupational Health. He obtained his Dr. Sci. degree in medicine and surgery from the University of Helsinki in 1981, and his Ph.D. degree in toxicology from the University of Kansas, USA, in 1987. His research covers inflammatory and genetic effects, and risk assessment of nanomaterials. He has served in numerous scientific expert committees, and has led several large research consortia on nanosafety. He also coordinates the EU NanoSafety Cluster, a platform of all EU FP-funded nanosafety projects.

Affiliations and Expertise

Ph.D. Nanosafety Research Center Finnish Institute of Occupational Health

Information about this author is currently not available.
Information about this author is currently not available.
Information about this author is currently not available.
Information about this author is currently not available.

Handbook of Nanosafety, 1st Edition



List of Contributors


Chapter 1. General Introduction


1.1 Use and Applications of Engineered Nanomaterials

1.2 What is a Nanomaterial?

1.3 Exposure to Engineered Nanomaterials Merits Attention

1.4 How to Measure Exposure to Engineered Nanomaterials

1.5 How About the Hazards?

1.6 Requirements for the Assessment and Management of Risks of Engineered Nanomaterials

1.7 To be Expected in the Future

1.8 Conclusions


Chapter 2. Nanotechnology and Exposure Scenarios



2.1 Introduction

2.2 Development of Nanotechnology

2.3 Production of Engineered Nanomaterials

2.4 Applications of Nanotechnology

2.5 Exposure Scenarios for Nanomaterials

2.6 Exposure Scenario Case Examples

2.7 Summary


Chapter 3. Nanomaterials and Human Health


3.1 Introduction

3.2 Biokinetics, Cardiovascular and Neurotoxicity of Engineered Nanomaterials

3.3 Inflammatory Effects of Engineered Nanomaterials

3.4 Nanomaterial-Induced Pulmonary Inflammation

3.5 Nanomaterial-Induced Skin Inflammation

3.6 Genotoxicity of Engineered Nanomaterials

3.7 Carcinogenicity of Engineered Nanomaterials

3.8 Implications of Health Effects and Safety of Engineered Nanomaterials for Nanotechnologies

3.9 Conclusions


Chapter 4. From Source to Dose: Emission, Transport, Aerosol Dynamics and Dose Assessment for Workplace Aerosol Exposure


4.1 Sources of Nanoparticles in the Workplace (Seipenbusch)

4.2 Aerosol Dynamics in Workplace Atmospheres (Seipenbusch)

4.3 Modelling Approaches to Aerosol Dynamics and Transport in the Workplace (Yu)

4.4 Applications of Aerosol Dynamics and Flow Modelling to Workplace Exposure (Mingzhou Yu)

4.5 Modelling of the Evolution of a Nanoparticle Aerosol in a Simulated Workplace (Asbach, Rating, Kuhlbusch)


4.6 Dose Assessment (Lidén)


Chapter 5. Monitoring and Sampling Strategy for (Manufactured) Nano Objects, Agglomerates and Aggregates (NOAA): Potential Added Value of the NANODEVICE Project


5.1 Introduction

5.2 Measurement Principles and Instrumentation

5.3 Measurement Strategy

5.4 New Devices (Pre-Prototypes) Developed by NANODEVICE and Implications for Measurement Strategies

5.5 Conclusions


Chapter 6. Quality Control of Measurement Devices – What Can Be Done to Guarantee High-Quality Measurements?


6.1 Responsibilities of the manufacturers (Horn)

6.2 Responsibilities of the Users (Dahmann)

6.3 External Instrument Comparison (Asbach)


Chapter 7. Examples and Case Studies


7.1 Introduction

7.2 Emission Chambers, a Method for Nanosafety (Le Bihan, Morgeneyer, Shandilya, Aguerre, Bressot)

7.3 Exposure of Workers to Carbon Nanotubes in a Commercial Production Facility; Preliminary Results in the Frame of Risk Assessment and Risk Management (Lecloux, Gorbunov, Brouwer, Muir)

7.4 Investigations on CNT Release from Composite Materials During end of Life (Stahlmecke, Asbach, Todea, Kaminski, Kuhlbusch)

7.5 The Need for Speed: Detection and Characterization of Particle Release During Powder Handling Using On-line Monitors (Jensen, Koponen)

7.6 Particulate Emissions from Equipment Used In Ultra Clean Areas of the Semiconductor Industry (Gommel, Keller)


Chapter 8. Risk Assessment and Risk Management



8.1 Introduction

8.2 Basic Approaches to Control Exposure to Hazardous Substances (by Thomas Brock)

8.3 Hierarchy of Control

8.4 Excursus: Safe Handling of Nanomaterials in the Laboratory

8.5 Health Risk Management of Engineered Nanomaterials

8.6 Risk Governance, Policy Aspects and Legislation in the European Union and the United States



Chapter 9. Future Outlook of Engineered Nanomaterials and Nanotechnologies



9.1 Introduction

9.2 New Principles for Engineered Nanomaterials Risk and Safety Governance

9.3 Key Areas of Nanosafety Research and the Expected Achievements in these Research Areas

9.4 Future Health and Safety Requirements of Nanomaterials and Nanotechnologies and Identification of the Knowledge Needs and Gaps

9.5 The Complexity of Nanomaterials and their Control and Regulation

9.6 Progress of Nanotechnologies on Safety Requirements of Nanomaterials and Technologies

9.7 Conclusions



Quotes and reviews

"Most of the information is from the NANODEVICE research project funded by the European Union, but the findings often integrate results of other research as well. Contributors from a wide range of sciences cover nanotechnology and exposure scenarios; nanomaterials and human health…"--ProtoView.com, April 2014

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