Françoise Gueritte

Françoise Gueritte

Françoise Gueritte completed her Ph.D thesis on 3° Cycle (1976) - Université Paris XI, Orsay. Between 1977-1979, she held Post-Doctoral positions (NIH Grant) at the Department of Chemistry, Yale University, USA and Department of Chemistry, Texas A&M University, USA. Laboratory of Professeur A. Ian Scott. In 1981, she was appointed "Chargée de Recherche" at INSERM. Today, she is Research Director of INSERM (Institut National de la Santé et de la Recherche Médicale) and team manager of the “Pôle Substance Naturelle-Plantes” at ICSN (Institut de Chimie des Substances Naturelles) - CNRS (Centre national de la Recherche Scientifique). She has submitted 144 research papers and holds 9 patents. Her team specialize in the isolation and chemistry of natural bioactive products. They are looking for natural products that 1) could be used as ligands to study biological targets in the fields of cancer, infectiology, neglected diseases, etc., 2) may serve as “hits” for further optimization and drug development, and 3) could be used as mimics for the synthesis of new molecules with biological properties. They have already succeeded in isolating molecules that interact with anti-apoptotic proteins, kinases, tubulin, proteins involved in the RSV replication, RNA polymerase of flavivirus, etc., and are inhibitors of viral replication, plasmodium or cancer cell growth. The team is also involved in the synthesis and structure-activity relationships of natural compounds interacting with tubulin and anti-apoptotic proteins.

Affiliations and Expertise

Research Director INSERM (Institut National de la Santé et de la Recherche Médicale); Team manager of the “Pôle Substance Naturelle-Plantes” at ICSN (Institut de Chimie des Substances Naturelles) - CNRS (Centre national de la Recherche Scientifique)