Comprehensive Biophysics

Comprehensive Biophysics, 1st Edition

Comprehensive Biophysics, 1st Edition,Edward Egelman,ISBN9780123749208

E Egelman   

Academic Press




Unites the different areas of biophysical research and allows users to navigate through the most essential concepts with ease

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Key Features

    • Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding.
    • The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research.
    • Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.


    Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics will help bridge that communication gap.

    Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge.


    Researchers, advanced undergraduate and graduate students, postdoctoral fellows, senior investigators, corporate customers (such as biotech companies) and libraries from Physics, Chemistry and Life Sciences departments.

    Edward Egelman

    Edward Egelman received a BA in physics and a PhD in biophysics from Brandeis University. He was a postdoctoral fellow at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, and then an assistant professor at Yale University. He was an associate and full professor at the University of Minnesota Medical School, and then moved to the University of Virginia in 1999 where he is a professor of biochemistry and molecular genetics. He is currently editor-in-chief of Biophysical Journal. He has been elected a fellow of the Biophysical Society and of the American Academy of Microbiology. His research focuses on the structure and function of macromolecular complexes, mainly using electron cryo-microscopy and computational image analysis. He has spent many years studying the structure of F-actin, as well as helical nucleoprotein complexes formed by recombination proteins (such as the bacterial RecA and the eukaryotic Rad51) on DNA.

    Affiliations and Expertise

    Editor-in-chief of Biophysical Journal. Elected fellow of the Biophysical Society and of the American Academy of Microbiology.

    Comprehensive Biophysics, 1st Edition

    Volume 1: Biophysical Techniques for Structural Characterization of Macromolecules (Jane Dyson, The Scripps Research Institute, CA, USA)

    Volume 2: Biophysical Techniques for Characterization of Cells (Petra Schwille, TU Dresden, Dresden, Germany)

    Volume 3: The Folding of Proteins and Nucleic Acids (Valerie Daggett, University of Washington, WA, USA)

    Volume 4: Molecular Motors and Motility (Yale Goldman & E. Michael Ostap, University of Pennsylvania, PA, USA)

    Volume 5: Membranes (Lukas Tamm, University of Virginia, VA, USA)

    Volume 6: Channels (Mauricio Montal, University of California, San Diego, CA, USA)

    Volume 7: Cell Biophysics (Denis Wirtz, Johns Hopkins University, Baltimore, MD, USA)

    Volume 8: Bioenergetics (Stuart Ferguson, University of Oxford, UK)

    Volume 9: Simulation and Modeling (Harel Weinstein, Weill Cornell Medical College, NY, USA)


    Full list of contents:

    Cantor and Schimmel - 30 Years Later
    Efficient Strategies for Production of Eukaryotic Proteins
    X-ray Crystallography: Crystallization
    X-ray crystallography | Data Collection Strategies and Resources
    X-ray crystallography | Phasing of X-ray Data
    X-ray crystallography | Refinement of X-ray Crystal Structures
    X-ray crystallography | Structure Validation and Analysis
    NMR Spectroscopy | Solution methods
    NMR Spectroscopy | Solid state NMR methods
    NMR Spectroscopy | Membrane protein methods: The hybrid solution/solid-state NMR method
    NMR Spectroscopy | Labeling techniques
    NMR Spectroscopy | NMR Relaxation methods
    Electron microscopy | 2D crystals
    Electron microscopy | Cryo-Electron Microscopy and Tomography of Virus Particles
    Mass spectrometry
    Ultrafast structural dynamics of biological systems
    Electron Magnetic Resonance
    Computing structure, dynamics, and thermodynamics of proteins
    Rapid Mixing Techniques for the Study of Enzyme Catalysis
    Other spectroscopy - UV-Vis, CD, Raman, vibrational CD applied in biophysical research
    Fluorescence and FRET: Theoretical Concepts 101
    Elucidating cellular structures | Confocal laser scanning microscopy
    Elucidating cellular structures | Two-photon microscopy
    Elucidating cellular structures | Fluorescence Lifetime Microscopy
    Elucidating cellular structures | Structured Illumination techniques
    Elucidating cellular structures | Superresolution Microscopy
    Elucidating cellular structures | Structure determination of macromolecular complexes by cryo-electron microscopy in vitro and in situ
    Visualizing sub-cellular organization using soft x-ray tomography
    Elucidating Cellular Structures | Atomic Force Microscopy
    Superresolution Near-field Optical Microscopy
    Elucidating cellular structures | CARS Microscopy
    Elucidating cellular dynamics: Quantitative Fluorescent Speckle Microscopy
    Elucidating cellular dynamics | FRAP
    Elucidating cellular dynamics | Fluorescence Correlation Spectroscopy
    Elucidating cellular dynamics | Image Correlation Spectroscopy
    Elucidating cellular dynamics | Single molecule tracking
    Protein Folding | Combining simulation and experiment to map protein folding (overview)
    Energetics of Protein Folding
    Globular Proteins | Fast events in protein folding
    Globular Proteins | Intermediates in protein folding
    Globular Proteins | Characterization of the denatured state
    Globular Proteins | Single Molecule Spectroscopy in Protein Folding
    Force-induced unfolding
    Protein and Nucleic Acid Folding | Domain swapping in Proteins
    Intrinsically Disordered Proteins
    Globular Proteins | Chaperones and protein folding
    Globular Proteins | Protein switches
    The folding of repeat proteins
    The membrane factor: biophysical studies of alpha helical transmembrane protein folding
    Nucleic Acid Folding | Prediction of nucleic acid structure
    Nucleic Acid Folding | Effect of protein binding on RNA folding
    General Theoretical Considerations
    Actin | Structure and Dynamic States of Actin Filaments
    Actin | Actin Filament Nucleation and Elongation
    Mechanical Properties of Actin Networks
    Microtubules | Structure of Microtubules
    Microtubules | Microtubule Nucleation, Polymerization and Mechanics
    Microtubules | Force Generation By Dynamic Microtubule Polymers
    Myosin | Myosin Motors: Structural Aspects and Functionality
    Myosin | Kinetics of Myosin
    Myosin | Single Molecule Fluorescence Techniques for Myosin
    Myosin | Single Molecule Force Measurements on Myosins
    Muscle | Muscle Fiber Mechanics and Force Generation
    Muscle | Muscle Spectroscopy
    Muscle | Thin Filament Regulation
    Muscle | Smooth Muscle and Myosin Regulation
    Intracellular transport: relating single-molecule properties to in vivo function
    Non-Muscle Motility | Mitosis
    Kinesin | Kinesin Structure & Biochemistry
    Kinesin | Single-molecule Mechanics
    Kinesin | Kinesin-related proteins: one engine, many machines
    Dynein | Cytoplasmic Dynein: its ATPase Cycle and ATPase-dependent Structural Changes
    Dynein | The Mechanics of Dynein Motility
    Dynein | Axonemal Motility
    Nucleic Acid Motors | DNA processing enzymes
    Nucleic Acid Motors | The Ribosome
    Nucleic Acid Motors | Viral Portal Motors
    Lipid Bilayers | Lipid Bilayer Structure
    Lipid Bilayers | Conformational Dynamics of Lipids in Membranes
    Lipid Bilayers | Membrane phases and domains
    Lipid Bilayers | Atomic Force Microscopy and Fluorescence Microscopy
    Membrane Proteins | Membrane Protein Structures
    Membrane Proteins | Solution NMR of membrane Proteins
    Membrane Proteins | AFM and EM of Membrane Proteins
    Membrane Proteins | Structure and Folding of Outer Membrane Proteins
    Protein Interactions with Membranes | Interactions of Antimicrobial Peptides with Lipid Bialyers
    Protein Interactions with Membranes | Membrane Electrostatics
    Protein Interactions with Membranes | Pore Forming Toxins
    Protein Interactions with Membranes | Membrane Recruitment of Signaling Domains
    Protein Interactions with Membranes | Supported Membranes - Structure and Interactions
    Protein Interactions with Membranes | Membrane Protein-Lipid Match and Mismatch
    Membrane Conformational Transitions | Membrane Fusion - general overview
    Membrane Conformational Transitions | Mechanisms of Enveloped Virus Entry by Membrane Fusion
    Membrane Dynamics | Single Molecule Tracking in Membranes
    Membrane Dynamics | Computational Methods to Model Membrane Dynamics
    Detergent interactions with lipid bilayers
    Molecular Modeling approaches to understand mechanisms in Voltage-Gated Channels
    Connexin Channels
    Structure-function correlates of Glutamate-Gated ion channels
    Gating Dynamics of the Potassium Channel Pore
    Biophysics of TRP channels
    Structure and mechanisms in chloride channels
    Biophysics of Ceramide Channels
    Voltage gated proton channels
    Store-operated Calcium Channels
    Bacterial Toxin channels
    Viral channels
    Structure-Function Correlates in Plant Ion Channels
    Biophysics of cell-matrix adhesion
    Biophysics of selectin-mediated cell-cell adhesions
    Biophysics of cadherin-mediated cell-cell adhesion
    Biophysics of cell division - Understanding how dividing cells change shape
    Biophysics of bacterial cell growth and division
    Biophysics of three-dimensional cell motility
    Cell microrheology
    Biophysics of nuclear organization and dynamics
    Cell-extracellular matrix mechanobiology in cancer
    Biophysics of cell motility
    Biophysics of cell developmental processes: A lasercutter’s perspective
    Biophysics of bacterial organization
    Structure and function of ATP synthase
    Structure-function relationships in P-type ATPases
    Rotational catalysis by the ATP synthase
    The Rotary Bacterial Flagellar Motor
    Electron Transfer Chains: Structures, Mechanisms and Energy Coupling
    Light capture in photosynthesis
    Photosystems of bacteria and plants
    A B C Transporters
    The mitochondrial family of transport proteins
    Bacteriorhodopsin and Related Proteins
    Transporters and Co-Transporters in Theory and Practice
    Structure function relationships in membrane transport prtotreins of the MFS and leu-T families (approximate)
    In silico approches to structure and function of cell components and their aggregates | Coarse grained methods: Theory
    In silico approches to structure and function of cell components and their aggregates | Coarse grained methods:Applications to allosteric proteins
    In silico approches to structure and function of cell components and their aggregates | Coarse grained methods: Applications to membranes
    In silico approches to structure and function of cell components and their aggregates | Dynamics of very large systems: the ribosome
    In silico approches to structure and function of cell components and their aggregates | New Technologies for Molecular Dynamics Simulations
    Simulations of molecular machines | Transporters
    Simulations of molecular machines | GPCRs
    Simulations of molecular machines | Enzymes: method advances
    MNDO-PSDCI Theory and the Excited States of Biological Chromophores
    In silico approches to structure and function of cell components and their assemblies | Electrostatic properties
    Modeling of interaction networks in the cell | Theory and mathematical methods
    Mathematical modeling of complex biological systems | From genes and molecules to organs and organisms: Heart
    Mathematical modeling of complex biological systems | From genes and molecules to organs and organisms: Kidney
    Mathematical modeling of complex biological systems | From genes and molecules to organs and organisms: Immune System







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