Comprehensive Biomaterials

Comprehensive Biomaterials, 1st Edition

Comprehensive Biomaterials, 1st Edition,Paul Ducheyne,Paul Ducheyne,Kevin Healy,Dietmar E. Hutmacher,David W. Grainger,C. James Kirkpatrick,ISBN9780080552941

Ducheyne   &   Ducheyne   &   Healy   &   Hutmacher   &   Grainger   &   Kirkpatrick   

Elsevier Science



The new standard reference for students and researchers interested in any aspect of biomaterials science and engineering.

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Key Features

      • Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects
      • Presents appropriate analytical methods and testing procedures in addition to potential device applications
      • Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development


      Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: • Volume 1: Metallic, Ceramic and Polymeric Biomaterials • Volume 2: Biologically Inspired and Biomolecular Materials • Volume 3: Methods of Analysis • Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules • Volume 5: Tissue and Organ Engineering • Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors.


      This work is of interest to any student, researcher or engineer working in biomaterials, medicinal research, cell biology, tissue engineering, tissue physiology, regenerative medicine, microfabrication, and biomedical devices and applications.

      Paul Ducheyne

      Paul Ducheyne is Professor of Bioengineering and Professor of Orthopaedic Surgery Research at the University of Pennsylvania, Philadelphia, USA. He is the Director of its Center for Bioactive Materials and Tissue Engineering. He also is Special Guest Professor at the University of Leuven, Belgium. Paul Ducheyne has Materials Science and Engineering degrees from the K.U. Leuven. Belgium (M.Sc.: 1972; Ph.D.: 1976). With fellowships from the National Institutes of Health (International Postdoctoral Fellowship) and the Belgian American Educational Foundation (Honorary Fellowship), he performed postdoctoral research at the University of Florida. Paul Ducheyne has organized a number of symposia and meetings, such as the Fourth European Conference on Biomaterials (1983), the Engineering Foundation Conference on Bioceramics (1986) which led to the New York Academy of Sciences publication: "Bioceramics, material characteristics versus in vivo behavior", and the Sixth International Symposium on Ceramics in Medicine (1993). He has lectured around the world and serves or has served on the editorial board of more than ten scientific journals in the biomaterials, bioceramics, bioengineering, tissue engineering, orthopaedics and dental fields. He has been a member of the editorial board, and then an associate editor of Biomaterials, the leading biomaterials journal, since its inception in the late seventies. He has authored more than 300 papers and chapters in a variety of international journals and books, and he has edited 10 books. He has also been granted more than 40 US patents with international counterparts. His papers have been cited about 7000 times; his ten most visible papers have been cited more than 2000 times. Paul Ducheyne started his career in Europe. While at the K.U. Leuven, Belgium (1977 - 1983), he was one of the co-founders of the Post-Graduate Curriculum in Bioengineering. This program is now a full M.Sc. program in the School of Engineering and Applied Sciences. In those initial years, he was also chairman-founder of the chapter on Biomedical Engineering of the Belgian Engineering Society (Flemish section) and director of Meditek, the Flemish Government body created to promote Academia to Industry Technology Transfer in the area of Biomedical Engineering. Paul Ducheyne founded Gentis, Inc., which focuses on breakthrough concepts for spinal disorders. Previously, he founded Orthovita (NASDAQ: VITA) in 1992 and served as Chairman of its Board of Directors until 1999. Orthovita focuses on bioceramic implant materials for orthopaedics. Paul Ducheyne has been secretary of the European Society for Biomaterials, is Past President of the Society for Biomaterials (USA) and Past President of the International Society for Ceramics in Medicine. He has been recognized as a fellow of the American Association for the Advancement of Science (AAAS), fellow of the American Institute of Medical and Biological Engineering (AIMBE), and fellow of the International Association of Biomaterials Societies. He was the first Nanyang Visiting Professor at the Nanyang Institute of Technology, Singapore and he has received the C. William Hall Award from the Society for Biomaterials. Many of Paul Ducheyne's trainees have become leaders of the next generation. Among his trainees are professors at the University of California at Berkeley, the University of Michigan, Columbia University, Georgia Institute of Technology, the K.U. Leuven (Belgium), etc... Among the six U.S. Associate Editors of the Journal for Biomedical Materials Research (the Journal of the Society for Biomaterials), three were his PhD students.

      Affiliations and Expertise

      University of Pennsylvania, Philadelphia, PA, USA

      Information about this author is currently not available.

      Kevin Healy

      Kevin E. Healy, Ph.D. is the Jan Fandrianto Distinguished Professor in Engineering at the University of California at Berkeley in the Departments of Bioengineering and Materials Science and Engineering. He received a Bachelor of Science degree from the University of Rochester in Chemical Engineering in 1983. In 1985 he received a Masters of Science degree in Bioengineering from the University of Pennsylvania, and in 1990 he received a Ph.D. in Bioengineering also from the University of Pennsylvania. He was elected a Fellow of the American Institute of Medical and Biological Engineering in 2001. He has authored or co-authored more than 200 published articles, abstracts, or book chapters which emphasize the relationship between materials and the tissues they contact. His research interests include the design and synthesis of biomimetic materials that actively direct the fate of embryonic and adult stem cells, and facilitate regeneration of damaged tissues and organs. Major discoveries from his laboratory have centered on the control of cell fate and tissue formation in contract with materials that are tunable in both their biological content and mechanical properties. These materials find applications in medicine, dentistry, and biotechnology. He is currently an Associate Editor of the Journal of Biomedical Materials Research. He has served on numerous panels and grant review study sections for N.I.H. He has given more than 200 invited lectures in the fields of Biomedical Engineering and Biomaterials. He is a named inventor on numerous issued United States and international patents relating to biomaterials, and has founded several companies to develop materials for applications in biotechnology and regenerative medicine.

      Affiliations and Expertise

      University of California, Berkeley, Berkeley, CA, USA

      Dietmar E. Hutmacher

      Professor Dietmar W. Hutmacher holds an accomplished international profile and strong research focus in the field of biomaterials, tissue engineering and regenerative medicine. Outcomes from Prof. Hutmacher's research have resulted in high profile scientific and academic contributions as well as patents and commercialization. He was named as one of the world's top materials scientist by Thomson Reuters in 2010 (ranked 45 out of the top 100). Prof. Hutmacher's track record shows that he has successfully mastered the main challenge in the biomedical sciences field, namely to cross traditional boundaries to nurture and initiate research and educational programs across different disciplines, particularly within engineering, biology and medicine.

      Affiliations and Expertise

      Queensland University of Technology, Brisbane, QLD, Australia

      David W. Grainger

      David W. Grainger is the George S. and Dolores Doré Eccles Presidential Endowed Chair in Pharmaceutics and Pharmaceutical Chemistry, Chair of the Department of Pharmaceutics and Pharmaceutical Chemistry, and Professor of Bioengineering at the University of Utah. Grainger received his Ph.D. in Pharmaceutical Chemistry from the University of Utah in 1987 studying blood-compatible polymers, particularly block copolymers functionalized with heparin blocks and their coatings. He then received an Alexander von Humboldt Fellowship to perform postdoctoral research under Prof. Helmut Ringsdorf, University of Mainz, Germany. This training initiated over 25 years of experience with various aspects of developing "materials in medicine". Grainger's research expertise is focused on improving implanted medical device performance, drug delivery of new therapeutic proteins, nucleic acids and live vaccines, nanomaterials interactions with human tissues, low-infection biomaterials, and innovating diagnostic devices based on DNA and protein biomarker capture. Additionally, he is an expert in applications of surface analytical methods to biomedical interfaces, including difficult surface patterns and nanomaterials, and perfluorinated biomaterials. Grainger has published over 130 full research papers at the interface of materials innovation in medicine and biotechnology, and novel surface chemistry. He has won research several awards, including the prestigious 2007 Clemson Award for Basic Research, Society for Biomaterials, and the 2005 American Pharmaceutical Research and Manufacturer's Association's award for "Excellence in Pharmaceutics". He won a short-term visiting professorship in Tokyo from the Japanese Society for the Promotion of Science, and a CNRS Visiting Professorship in Paris, France. He has also received several teaching awards for outstanding mentoring and teaching service, including the University of Utah 2010 Distinguished Postdoctoral and Graduate Student Mentoring Award, the US West/Qwest Faculty Education Excellence Award (Colorado State University, 2000), Colorado State University College of Natural Sciences "Undergraduate Teacher of the Year", 2000, Colorado State University Alumni Association "Teacher of the Year", 2002, and several "Favorite Faculty" Awards from CSU Undergraduate Student Associations. Grainger delivered the EU Madame Curie guest lectures at the Technical University-Aachen, Germany in 2009 and the 15th Annual Fritz Straumann lecture, AO Foundation, Davos, Switzerland, December, 2008. Grainger is an elected Fellow of both the American Association for the Advancement of Science (AAAS) and the American Institute of Medical and Biological Engineering (AIMBE), and Inducted Honorary Fellow, International Union of the Societies of Biomaterials Science and Engineering, 2008. He has organized 23 international scientific symposia including the prestigious Gordon Research Conference in Biomaterials, presented over 320 hundred invited talks all over the world. He serves on editorial boards for 4 major research journals in the biomedical materials field, reviewing over 50 manuscripts annually. He is Chair and standing member of Emerging Bioanalytical Technologies scientific review group (SRG) at NIH, past standing member on the NIH's Surgery and Bioengineering SRG, and over 20 other NIH and NSF review panels, some as chair. Additionally, he serves on the Scientific Advisory Boards of the Univ. Wisconsin-Madison NSF MRSEC on High Performance Nanostructured Materials, the NIH P41 National Research Center at the University of Washington (NESAC/Bio) for surface analysis for biomedical problems, NSF Harvard/New Mexico NSF PREM MRSEC, and several international research foundations (AO Foundation, Davos, Switzerland, Swiss Center for Materials Competence, Zurich, the Willem S. Kolff Institute, Royal University

      Affiliations and Expertise

      University of Utah, Salt Lake City, UT, USA

      C. James Kirkpatrick

      C. James Kirkpatrick is currently Professor of Pathology and Chairman of the Institute of Pathology at the Johannes Gutenberg University of Mainz, Germany, having taken up this position in 1993. He is also Honorary Professor at both the Peking Union Medical College, Beijing and the Sichuan University, Chengdu in China. Kirkpatrick is a graduate of the Queen's University of Belfast and holds a triple doctorate in science and medicine (PhD: 1977; MD: 1982; DSc: 1992). Previous appointments were in pathology at the University of Ulm, where he did post-doctoral research in experimental pathology, Manchester University (Lecturer in Histopathology) and the RWTH Aachen (Professor of Pathology & Electron Microscopy). On moving to Aachen in 1987 he established a cell culture laboratory which began using modern methods of cell and molecular biology to study how human cells react to biomaterials. Since then his principal research interests continue to be in the field of biomaterials in tissue engineering and regenerative medicine, with special focus on the development of human cell culture techniques, including novel 3D coculture methodology for biomaterials. His research laboratory, the REPAIR-lab, is a member of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, and his research is principally funded by the EU, BMBF (German Federal Ministry of Education and Research), BMVg (German Federal Ministry of Defence) and the DFG (German Research Foundation). This emphasis on developing sophisticated in vitro techniques has brought him the Research Prize of the State of Rhineland-Palatinate for Research on Replacement and Alternative Methods for Animal Research. In 2010 he received, as first medical graduate, the Chapman Medal from the Institute of Materials, Minerals & Mining in London for "distinguished research in the field of biomedical materials". He is author/coauthor of more than 380 publications in peer-reviewed journals and has made more than 1000 presentations to scientific meetings worldwide. He is a former President of both the German Society for Biomaterials (2001-2005) and the European Society for Biomaterials (2002-2007; George Winter Award 2008) and has served on the Council of the latter since 1995. Kirkpatrick is a long-standing member of the Editorial Board of the premier journal Biomaterials and is a current Associate Editor (since 2002). He has also served as Associate Editor of the leading Journal of Pathology (2001-2006). In total, he serves or has served as an Editorial Board member of 18 international journals in pathology, biomaterials and tissue engineering. Kirkpatrick is a member of the Scientific Advisory Board of a number of research institutes, centres of excellence and companies in biomaterials and regenerative medicine in Europe, as well as the Medical Technology Committee, Federal Ministry of Education & Research in Germany (BMBF) (since 2005) and the German Federal Institute for Drugs & Medical Devices (BfArM)(since 2007). During his entire research career, Kirkpatrick has actively practiced diagnostic histopathology, which has allowed him to apply modern molecular pathology techniques to the study of biofunctionality of biomaterials. Since 1997 he is a Fellow of the Royal College of Pathologists, London and since 1995 a Fellow of Biomaterials Science & Engineering (FBSE) of the IUS-BSE (International Union of Societies for Biomaterials Science & Engineering). He is also in a second term of service on the Council of the European Chapter of the Tissue Engineering & Regenerative Medicine International Society (TERMIS-EU). Kirkpatrick had also had the privilege of chairing the Scientific Programme Committee for the 8th World Biomaterials Congress in Amsterdam in 2008.

      Affiliations and Expertise

      Johannes Gutenburg University Medical Center, Mainz, Germany

      Comprehensive Biomaterials, 1st Edition

      Volume 1: Metallic, Ceramic and Polymeric Biomaterials

      1.101 Biomaterials


      1.102 Metals for Use in Medicine

      1.103 Electrochemical Behavior of Metals in the Biological Milieu

      1.104 Shape Memory Alloys for Use in Medicine

      Ceramics – Inert Ceramics

      1.105 Alumina

      1.106 Zirconia as a Biomaterial

      1.107 Carbon and Diamond

      1.108 Wear-Resistant Ceramic Films and Coatings

      Ceramics – Bioactive Ceramics

      1.109 Bioactive Ceramics

      1.110 Bioactive Glass-Ceramics

      1.111 Bioactive Ceramics: Physical Chemistry

      1.112 Calcium Phosphate Coatings

      1.113 Bioactive Layer Formation on Metals and Polymers

      1.114 Bioactivity: Mechanisms

      1.115 Calcium Phosphates for Cell Transfection

      1.116 Bioactive Ceramics: Cements

      1.117 Phosphate-Based Glasses

      1.118 Calcium Phosphate Ceramics with Inorganic Additives

      1.119 Silicon-Containing Apatites

      1.120 Synthetic Bone Grafts: Clinical Use


      1.121 Polymer Fundamentals: Polymer Synthesis

      1.122 Structural Biomedical Polymers (Nondegradable)

      1.123 Degradable Polymers

      1.124 Polymer Films Using LbL Self-Assembly

      1.125 Polyurethanes and Silicone Polyurethane Copolymers

      1.126 Shape-Memory Polymers

      1.127 Electrospinning and Polymer Nanofibers: Process Fundamentals

      1.128 Fluorinated Biomaterials

      1.129 Engineering the Biophysical Properties of Basement Membranes into Biomaterials: Fabrication and Effects on Cell Behavior

      1.130 Electroactive Polymeric Biomaterials

      1.131 Superporous Hydrogels for Drug Delivery Systems

      1.132 Dynamic Hydrogels

      Volume 2: Biologically Inspired and Biomolecular Materials

      Biologically Inspired and Biomolecular Materials and Interfaces

      2.201 Bio-inspired Silica Nanomaterials for Biomedical Applications

      2.202 Engineering Viruses For Gene Therapy

      2.203 Protein-Engineered Biomaterials: Synthesis and Characterization

      2.204 Peptoids: Synthesis, Characterization, and Nanostructures

      2.205 Self-Assembling Biomaterials

      2.206 Phages as Tools for Functional Nanomaterials Development

      2.207 Extracellular Matrix: Inspired Biomaterials

      2.208 Artificial Extracellular Matrices to Functionalize Biomaterial Surfaces

      2.209 Materials as Artificial Stem Cell Microenvironments

      Materials of Biological Origin

      2.210 Bone as a Material

      2.211 Polymers of Biological Origin

      2.212 Silk Biomaterials

      2.213 Chitosan

      2.214 Hyaluronic Acid

      2.215 Collagen: Materials Analysis and Implant Uses

      2.216 Collagen–GAG Materials

      2.217 Fibrin

      2.218 Elastin Biopolymers

      2.219 Biophysical Analysis of Amyloid Formation

      2.220 Extracellular Matrix as Biomimetic Biomaterial: Biological Matrices for Tissue Regeneration

      2.221 Decellularized Scaffolds

      2.222 Xenogenic Tissues and Biomaterials for the Skeletal System

      2.223 Bacterial Cellulose as Biomaterial

      Volume 3: Methods of Analysis

      Surface and Other Instrumental Analysis

      3.301 Surface Analysis and Biointerfaces: Vacuum and Ambient In Situ Techniques

      3.302 Atomic Force Microscopy

      3.303 Proteomic and Advanced Biochemical Techniques to Study Protein Adsorption

      3.304 Developments in High-Resolution CT: Studying Bioregeneration by Hard X-ray Synchrotron-Based Microtomography

      Mechanical Analysis

      3.305 Biomedical Thin Films: Mechanical Properties

      3.306 Microindentation

      Computational Analyses and Modeling

      3.307 Finite Element Analysis in Bone Research: A Computational Method Relating Structure to Mechanical Function

      3.308 The Mechanics of Native and Engineered Cardiac Soft Tissues

      3.309 Fluid Mechanics: Transport and Diffusion Analyses as Applied in Biomaterials Studies

      3.310 Computational Methods Related to Reaction Chemistry

      3.311 Molecular Simulation Methods to Investigate Protein Adsorption Behavior at the Atomic Level

      Biological and Tissue Analyses

      3.312 Cell Culture Systems for Studying Biomaterial Interactions with Biological Barriers

      3.313 Histological Analysis

      3.314 Materials to Control and Measure Cell Function

      3.315 Biological Microelectromechanical Systems (BioMEMS) Devices

      3.316 Immunohistochemistry

      3.317 Fluorescence Imaging of Cell–Biomaterial Interactions

      3.318 Molecular Imaging

      3.319 Characterization of Nanoparticles in Biological Environments

      3.320 Nanostructured Polymeric Films for Cell Biology

      3.321 Microarrays in Biomaterials Research

      In Vivo and Ex Vivo Imaging

      3.322 Infrared and Raman Microscopy and Imaging of Biomaterials

      3.323 Magnetic Resonance of Bone Microstructure and Chemistry

      3.324 Fluorescent Nanoparticles for Biological Imaging

      3.325 Imaging Mineralized Tissues in Vertebrates

      3.326 Imaging and Diagnosis of Biological Markers


      3.327 Intracellular Probes

      3.328 Biosensors Based on Sol–Gel-Derived Materials

      3.329 Hydrogels in Biosensing Applications

      3.330 Carbon Nanotube-Based Sensors: Overview

      3.331 Conjugated Polymers for Biosensor Devices

      Volume 4: Biocompatibility, Surface Engineering, and Delivery of Drugs, Genes and Other Molecules


      4.401 The Concept of Biocompatibility

      4.402 Biocompatibility and the Relationship to Standards: Meaning and Scope of Biomaterials Testing

      4.403 The Innate Response to Biomaterials

      4.404 Adaptive Immune Responses to Biomaterials

      4.405 Leukocyte–Biomaterial Interaction In Vitro

      4.406 Protein Interactions with Biomaterials

      4.407 Bacterial Adhesion and Biomaterial Surfaces

      4.408 Integrin-Activated Reactions to Metallic Implant Surfaces

      4.409 Surfaces and Cell Behavior

      4.410 Sterilization of Biomaterials of Synthetic and Biological Origin

      Surface Engineering

      4.411 Peptide- and Protein-Modified Surfaces

      4.412 Rational and Combinatorial Methods to Create Designer Protein Interfaces

      4.413 Patterned Biointerfaces

      4.414 Molecular Biomimetic Designs for Controlling Surface Interactions

      4.415 Surface Engineering Using Peptide Amphiphiles

      4.416 Growth Factors and Protein-Modified Surfaces and Interfaces

      4.417 Tethered Antibiotics

      4.418 Engineering Interfaces for Infection Immunity

      Synthesis and Structural Design for Drug and Gene Delivery

      4.419 Vaccine and Immunotherapy Delivery

      4.420 Drug Delivery via Heparin Conjugates

      4.421 Self-Assembled Prodrugs

      4.422 pH-Responsive Polymers for the Intracellular Delivery of Biomolecular Drugs

      4.423 Polymeric Drug Conjugates by Controlled Radical Polymerization

      4.424 Nanoparticles for Nucleic Acid Delivery

      4.425 Delivery of Nucleic Acids and Gene Delivery

      4.426 Electrospun Fibers for Drug Delivery

      4.427 Cell-Demanded Release of Growth Factors

      Inorganic and Hybrid Controlled Release Systems

      4.428 Sol–Gel Processed Oxide Controlled Release Materials

      4.429 Ordered Mesoporous Silica Materials

      4.430 Silica-Based Mesoporous Nanospheres

      4.431 Encapsulation of Cells (Cellular Delivery) Using Sol–Gel Systems

      4.432 Layered Double Hydroxides as Controlled Release Materials

      4.433 Porous Metal–Organic Frameworks as New Drug Carriers

      4.434 Hybrid Magnetic Nanoparticles for Targeted Delivery

      Volume 5: Tissue and Organ Engineering

      Tissue Engineering – Fundamentals

      5.501 Scaffolds: Flow Perfusion Bioreactor Design

      5.502 Engineering Scaffold Mechanical and Mass Transport Properties

      5.503 Biomaterials and the Microvasculature

      5.504 Effect of Substrate Modulus on Cell Function and Differentiation

      5.505 Quantifying Integrin–Ligand Engagement and Cell Phenotype in 3D Scaffolds

      5.506 Effects of Mechanical Stress on Cells

      5.507 Tissue Engineering and Selection of Cells

      5.508 Scaffold Materials for hES Cell Culture and Differentiation

      5.509 Cell Encapsulation

      5.510 Engineered Bioactive Molecules

      5.511 Rotating-Wall Vessels for Cell Culture

      5.512 In Vivo Bioreactors

      5.513 Systems Biology in Biomaterials and Tissue Engineering

      Tissue Engineering – Musculoskeletal, Cranial and Maxillofacial

      5.514 Chondrocyte Transplantation and Selection

      5.515 Cartilage Tissue Engineering

      5.516 Biomaterials in Cartilage Tissue Engineering

      5.517 Tissue Engineering of the Temporomandibular Joint

      5.518 Endocultivation: Computer Designed, Autologous, Vascularized Bone Grafts

      5.519 Biomaterials Selection for Dental Pulp Regeneration

      5.520 Bioactive Ceramics and Bioactive Ceramic Composite-Based Scaffolds

      5.521 Calcium Phosphates and Bone Induction

      5.522 Bone Tissue Engineering: Growth Factors and Cytokines

      5.523 Carbon Nanotubes: Applications for In Situ Implant Sensors

      5.524 Biomaterials for Replacement and Repair of the Meniscus and Annulus Fibrosus

      5.525 Tissue Engineering Approaches to Regeneration of Anterior Cruciate Ligament

      5.526 Tissue Engineering of Muscle Tissue

      Tissue Engineering - Cardiovascular

      5.527 Cardiovascular Tissue Engineering

      5.528 Tissue Engineering of Heart Valves

      5.529 Biomaterials for Cardiac Cell Transplantation

      5.530 Medical Applications of Cell Sheet Engineering

      Tissue Engineering, Neurological and Neurosurgical

      5.531 Peripheral Nerve Regeneration

      5.532 Nerve Tissue Engineering

      5.533 Biomaterials for Central Nervous System Regeneration

      Tissue Engineering – Other Tissues

      5.534 Skin Tissue Engineering

      5.535 Cartilage Regeneration in Reconstructive Surgery

      5.536 Tissue-Engineering Hollow Noncardiac Intrathoracic Organs: State-of-the-Art 2010

      5.537 Adipose Tissue Engineering

      5.538 Finger

      Organ Engineering

      5.539 From Tissue to Organ Engineering

      5.540 Kidney Tissue Engineering

      5.541 Liver Tissue Engineering

      5.542 Organ Printing

      Volume 6: Biomaterials and Clinical Use

      Orthopedic Surgery – Joint Replacement

      6.601 Current and Projected Utilization of Total Joint Replacements

      6.602 Bone Cement

      6.603 Ultrahigh Molecular Weight Polyethylene Total Joint Implants

      6.604 Ceramic Prostheses: Clinical Results Worldwide

      6.605 Porous Coatings in Orthopedics

      6.606 Biological Effects of Wear Debris from Joint Arthroplasties

      6.607 Fretting Corrosion of Orthopedic Implants

      6.608 Implant Debris: Clinical Data and Relevance

      6.609 Orthopedic Implant Use and Infection

      Orthopedic Surgery – Spinal Treatment

      6.610 Trends in Materials for Spine Surgery

      6.611 Injectable Bone Cements for Spinal Column Augmentation: Materials for Kyphoplasty/Vertebroplasty

      6.612 Biomaterials for Intervertebral Disc Regeneration

      6.613 Nucleus Replacement

      6.614 Wear: Total Intervertebral Disc Prostheses

      6.615 Intervertebral Disc

      Orthopedic Surgery – Fracture Fixation, Bone Grafting, Tendon and Ligament Repair

      6.616 Materials in Fracture Fixation

      6.617 Bone Tissue Grafting and Tissue Engineering Concepts

      6.618 Materials in Tendon and Ligament Repair

      Dentistry, and Oral and Maxillofacial Surgery

      6.619 Materials in Dental Implantology

      6.620 Dental Graft Materials

      6.621 Biomaterials and Their Application in Craniomaxillofacial Surgery

      6.622 The Effect of Substrate Microtopography on Osseointegration of Titanium Implants

      6.623 Materials in Fixed Prosthodontics for Indirect Dental Restorations

      Cardiology and Cardiovascular Surgery

      6.624 Cardiac Patch with Cells: Biological or Synthetic

      6.625 Long-Term Implantable Ventricular Assist Devices (VADs) and Total Artificial Hearts (TAHs)

      6.626 Cardiac Valves: Biologic and Synthetic

      6.627 Drug-Eluting Stents

      6.628 Vascular Grafts

      Other Surgical Disciplines: Neurology and Neurosurgery

      6.629 Cerebrospinal Fluid Shunts

      6.630 Biomaterials for Spinal Cord Repair

      Other Surgical Disciplines: Ophthalmology

      6.631 Keratoprostheses

      6.632 Retina Reconstruction

      6.633 Development of Contact Lenses from a Biomaterial Point of View – Materials, Manufacture, and Clinical Application

      Other Surgical Disciplines: General

      6.634 Bioartificial Kidney

      6.635 Surgical Adhesion and Its Prevention

      6.636 Suture Material: Conventional and Stimuli Responsive

      6.637 Staple Line Reinforcement Materials

      6.638 Biomaterials for Hernia Repair


      Quotes and reviews

      "In a highly technical and vastly broad subject area, the key to managing (mastering) reputable information and facilitating new breakthroughs is through its preservation and organization by experts in the field. For students or researchers wanting a quick introduction or a working knowledge of an unfamiliar subfield of biomaterials, the assembled chapters will be much more valuable than the typical documents that rise to the top of keyword searches. The authors and editors should be commended for their efforts and congratulated on producing an impressive reference of lasting value. In this reviewer's opinion, it will be an essential reference for any library affiliated with graduate programs in the biomedical sciences. Summing Up: Highly recommended. Upper-division undergraduates and above."--CHOICE

      "[T]his is a huge body of work and I would suspect the price would preclude individual researchers from acquiring the set; however, this is a must have for libraries as an up-to-date reference for the current state-of–the-art information in this field as well as a fundamental reference tome for researchers seeking an introduction to the field."--Journal of Biomaterials Applications, Vol. 26, February 2012, page 761


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