Comprehensive Biomaterials II

Comprehensive Biomaterials II, 2nd Edition

Comprehensive Biomaterials II, 2nd Edition,Paul Ducheyne,Kevin Healy,Dietmar E. Hutmacher,David W. Grainger,C. James Kirkpatrick,ISBN9780081006917

Ducheyne   &   Healy   &   Hutmacher   &   Grainger   &   Kirkpatrick   




276 X 216

This highly-detailed and expertly-written reference work is a thorough treatment on the diverse field of biomaterials

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Key Features

  • Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects
  • Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment
  • Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications


Comprehensive Biomaterials II, Second Edition brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications.

Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough.


Researchers, postgraduate students, lecturers and engineers working in biomaterials, medicinal research, cell biology, tissue engineering, tissue physiology, regenerative medicine, microfabrication, and biomedical devices and applications

Paul Ducheyne

Paul Ducheyne is Professor of Bioengineering at the University of Pennsylvania, Philadelphia, USA, and a member of the Institute for Medicine and Engineering (IME) and the Center for Engineering Cells and Regeneration (CECR). Paul's research is focused in the investigation of mechanistic effects of materials on cellular functions, specifically cell attachment, proliferation, differentiation and extracellular matrix formation, especially with respect to biomaterials and tissue engineering. His lab works extensively with the interface zone between materials and cells and tissues, using both materials science techniques as well as life science methods. In addition, studies focus on the combined effects of microgravity and substrate material on cellular functions and on material surface modification and controlled release of growth factors. Several tissue engineering applications are pursued with orthopedic and dental applications. Specifically, his laboratory studies whether bone defects can be repaired with full return of mechanical function by treating defects with in vitro synthesized bone tissue.

Affiliations and Expertise

University of Pennsylvania, Philadelphia, USA

Kevin Healy

Kevin E. Healy, Ph.D. is the Jan Fandrianto Distinguished Professor in Engineering at the University of California at Berkeley in the Departments of Bioengineering and Materials Science and Engineering. He received a Bachelor of Science degree from the University of Rochester in Chemical Engineering in 1983. In 1985 he received a Masters of Science degree in Bioengineering from the University of Pennsylvania, and in 1990 he received a Ph.D. in Bioengineering also from the University of Pennsylvania. He was elected a Fellow of the American Institute of Medical and Biological Engineering in 2001. He has authored or co-authored more than 200 published articles, abstracts, or book chapters which emphasize the relationship between materials and the tissues they contact. His research interests include the design and synthesis of biomimetic materials that actively direct the fate of embryonic and adult stem cells, and facilitate regeneration of damaged tissues and organs. Major discoveries from his laboratory have centered on the control of cell fate and tissue formation in contract with materials that are tunable in both their biological content and mechanical properties. These materials find applications in medicine, dentistry, and biotechnology. He is currently an Associate Editor of the Journal of Biomedical Materials Research. He has served on numerous panels and grant review study sections for N.I.H. He has given more than 200 invited lectures in the fields of Biomedical Engineering and Biomaterials. He is a named inventor on numerous issued United States and international patents relating to biomaterials, and has founded several companies to develop materials for applications in biotechnology and regenerative medicine.

Affiliations and Expertise

University of California, Berkeley, Berkeley, CA, USA

Dietmar E. Hutmacher

Professor Dietmar W. Hutmacher holds an accomplished international profile and strong research focus in the field of biomaterials, tissue engineering and regenerative medicine. Outcomes from Prof. Hutmacher's research have resulted in high profile scientific and academic contributions as well as patents and commercialization. He was named as one of the world's top materials scientist by Thomson Reuters in 2010 (ranked 45 out of the top 100). Prof. Hutmacher's track record shows that he has successfully mastered the main challenge in the biomedical sciences field, namely to cross traditional boundaries to nurture and initiate research and educational programs across different disciplines, particularly within engineering, biology and medicine.

Affiliations and Expertise

Queensland University of Technology, Brisbane, QLD, Australia

David W. Grainger

David W. Grainger is the George S. and Dolores Doré Eccles Presidential Endowed Chair in Pharmaceutics and Pharmaceutical Chemistry, Chair of the Department of Pharmaceutics and Pharmaceutical Chemistry, and Professor of Bioengineering at the University of Utah. Grainger received his Ph.D. in Pharmaceutical Chemistry from the University of Utah in 1987 studying blood-compatible polymers, particularly block copolymers functionalized with heparin blocks and their coatings. He then received an Alexander von Humboldt Fellowship to perform postdoctoral research under Prof. Helmut Ringsdorf, University of Mainz, Germany. This training initiated over 25 years of experience with various aspects of developing "materials in medicine". Grainger's research expertise is focused on improving implanted medical device performance, drug delivery of new therapeutic proteins, nucleic acids and live vaccines, nanomaterials interactions with human tissues, low-infection biomaterials, and innovating diagnostic devices based on DNA and protein biomarker capture. Additionally, he is an expert in applications of surface analytical methods to biomedical interfaces, including difficult surface patterns and nanomaterials, and perfluorinated biomaterials. Grainger has published over 130 full research papers at the interface of materials innovation in medicine and biotechnology, and novel surface chemistry. He has won research several awards, including the prestigious 2007 Clemson Award for Basic Research, Society for Biomaterials, and the 2005 American Pharmaceutical Research and Manufacturer's Association's award for "Excellence in Pharmaceutics". He won a short-term visiting professorship in Tokyo from the Japanese Society for the Promotion of Science, and a CNRS Visiting Professorship in Paris, France. He has also received several teaching awards for outstanding mentoring and teaching service, including the University of Utah 2010 Distinguished Postdoctoral and Graduate Student Mentoring Award, the US West/Qwest Faculty Education Excellence Award (Colorado State University, 2000), Colorado State University College of Natural Sciences "Undergraduate Teacher of the Year", 2000, Colorado State University Alumni Association "Teacher of the Year", 2002, and several "Favorite Faculty" Awards from CSU Undergraduate Student Associations. Grainger delivered the EU Madame Curie guest lectures at the Technical University-Aachen, Germany in 2009 and the 15th Annual Fritz Straumann lecture, AO Foundation, Davos, Switzerland, December, 2008. Grainger is an elected Fellow of both the American Association for the Advancement of Science (AAAS) and the American Institute of Medical and Biological Engineering (AIMBE), and Inducted Honorary Fellow, International Union of the Societies of Biomaterials Science and Engineering, 2008. He has organized 23 international scientific symposia including the prestigious Gordon Research Conference in Biomaterials, presented over 320 hundred invited talks all over the world. He serves on editorial boards for 4 major research journals in the biomedical materials field, reviewing over 50 manuscripts annually. He is Chair and standing member of Emerging Bioanalytical Technologies scientific review group (SRG) at NIH, past standing member on the NIH's Surgery and Bioengineering SRG, and over 20 other NIH and NSF review panels, some as chair. Additionally, he serves on the Scientific Advisory Boards of the Univ. Wisconsin-Madison NSF MRSEC on High Performance Nanostructured Materials, the NIH P41 National Research Center at the University of Washington (NESAC/Bio) for surface analysis for biomedical problems, NSF Harvard/New Mexico NSF PREM MRSEC, and several international research foundations (AO Foundation, Davos, Switzerland, Swiss Center for Materials Competence, Zurich, the Willem S. Kolff Institute, Royal University

Affiliations and Expertise

University of Utah, Salt Lake City, UT, USA

C. James Kirkpatrick

C. James Kirkpatrick is Emeritus Professor of Pathology at the Johannes Gutenberg University of Mainz, Germany, having directed the Institute of Pathology from 1993-2015. Currently he is Senior Professor in the Cranio-Maxillofacial Surgery Clinic at the Goethe University of Frankfurt & Visiting Professor of Biomaterials & Regenerative Medicine at the University of Gothenburg, Sweden. He is also Honorary Professor at the Peking Union Medical College, Beijing and the Sichuan University, Chengdu, China. Kirkpatrick is a graduate of the Queen’s University of Belfast and holds a triple doctorate in science and medicine (PhD: 1977; MD: 1982; DSc: 1992). Previous appointments were in pathology at the University of Ulm, where he did postdoctoral research in experimental pathology, Manchester University (Lecturer in Histopathology) and the RWTH Aachen (Professor of Pathology & Electron Microscopy). On moving to Aachen in 1987, he established a cell culture laboratory which began using modern methods of cell and molecular biology to study how human cells react to biomaterials. Since then, his principal research interests continue to be in the field of biomaterials in tissue engineering and regenerative medicine, with special focus on the development of human cell culture techniques, including novel 3D coculture methodology for biomaterials and the application of modern molecular pathology techniques to the study of biofunctionality of biomaterials, including nanomaterials. Kirkpatrick is author/coauthor of more than 500 publications in peer-reviewed journals and has given more than 500 invited presentations to scientific meetings worldwide. He has an H-index of 58 (Web of Science) and 68 (Google Scholar) and has been cited more than 17.000 times. He is a former president of both the German Society for Biomaterials (2001-2005) and the European Society for Biomaterials (2002-2007) and served on the ESB council from 1995-2013. He was also a member of the Council of the European Chapter of the Tissue Engineering & Regenerative Medicine International Society (TERMIS-EU; 2006-2008; 2010-2012). Kirkpatrick was a long-standing member of the editorial board of the premier journal Biomaterials (1996-2014) and also associate editor (2002-2014). He has also served as associate editor of the leading Journal of Pathology (2001-2006). In total, he serves or has served as an editorial board member of 18 international journals in pathology, biomaterials, and tissue engineering. Kirkpatrick was the Scientific Programme Committee Chair for the 8th World Biomaterials Congress in Amsterdam in 2008. Kirkpatrick is a member of the Scientific Advisory Board of a number of research institutes, centres of excellence and companies in biomaterials and regenerative medicine in Europe, as well as the Medical Technology Committee, Federal Ministry of Education & Research in Germany (BMBF) (2005-2008) and the German Federal Institute for Drugs & Medical Devices (BfArM)(since 2007). Kirkpatrick has been recognized for his contributions. He is a Fellow of the Royal College of Pathologists, London and a Fellow of Biomaterials Science & Engineering (FBSE) of the IUS-BSE (International Union of Societies for Biomaterials Science & Engineering). He received the Research Prize of the State of Rhineland-Palatinate for Research on Replacement and Alternative Methods for Animal Research. He was the recipient of the George Winter Award from the European Society for Biomaterials (2008), and in 2010, he received, as first medical graduate, the Chapman Medal from the Institute of Materials, Minerals & Mining in London for “distinguished research in the field of biomedical materials”. In 2014 Kirkpatrick received the TERMIS-EU Career Achievement Award.

Affiliations and Expertise

Johannes Gutenburg University Medical Center, Mainz, Germany

Comprehensive Biomaterials II, 2nd Edition

Volume 1: Metallic, Ceramic and Polymeric Biomaterials

Volume 2: Biologically Inspired and Biomolecular Materials

Volume 3: Methods of Analysis

Volume 4: Biocompatibility, Surface Engineering, and Delivery of Drugs, Genes and Other Molecules

Volume 5: Tissue and Organ Engineering

Volume 6: Biomaterials and Clinical Use

Quotes and reviews

Reviews of Comprehensive Biomaterials:
"For students or researchers wanting a quick introduction or a working knowledge of an unfamiliar subfield of biomaterials, the assembled chapters will be much more valuable than the typical documents that rise to the top of keyword searches. The authors and editors should be commended for their efforts and congratulated on producing an impressive reference of lasting value ... an essential reference for any library affiliated with graduate programs in the biomedical sciences." --Choice

"This is a must have for libraries as an up-to-date reference for the current state-of-the-art information in this field as well as a fundamental reference tome for researchers seeking an introduction to the field." --Journal of Biomaterials Applications

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