Comprehensive Biomaterials

Comprehensive Biomaterials, 1st Edition

Comprehensive Biomaterials, 1st Edition,Paul Ducheyne,Kevin Healy,Dietmar E. Hutmacher,David W. Grainger,C. James Kirkpatrick,ISBN9780080552941

Ducheyne   &   Healy   &   Hutmacher   &   Grainger   &   Kirkpatrick   

Elsevier Science



The new standard reference for students and researchers interested in any aspect of biomaterials science and engineering.

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Key Features

      • Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects
      • Presents appropriate analytical methods and testing procedures in addition to potential device applications
      • Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development


      Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: • Volume 1: Metallic, Ceramic and Polymeric Biomaterials • Volume 2: Biologically Inspired and Biomolecular Materials • Volume 3: Methods of Analysis • Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules • Volume 5: Tissue and Organ Engineering • Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors.


      This work is of interest to any student, researcher or engineer working in biomaterials, medicinal research, cell biology, tissue engineering, tissue physiology, regenerative medicine, microfabrication, and biomedical devices and applications.

      Paul Ducheyne

      Paul Ducheyne is Professor of Bioengineering and Professor of Orthopaedic Surgery Research at the University of Pennsylvania, Philadelphia, USA. He is the Director of its Center for Bioactive Materials and Tissue Engineering. He also is Special Guest Professor at the University of Leuven, Belgium. Paul Ducheyne has Materials Science and Engineering degrees from the K.U. Leuven. Belgium (M.Sc.: 1972; Ph.D.: 1976). With fellowships from the National Institutes of Health (International Postdoctoral Fellowship) and the Belgian American Educational Foundation (Honorary Fellowship), he performed postdoctoral research at the University of Florida. Paul Ducheyne has organized a number of symposia and meetings, such as the Fourth European Conference on Biomaterials (1983), the Engineering Foundation Conference on Bioceramics (1986) which led to the New York Academy of Sciences publication: "Bioceramics, material characteristics versus in vivo behavior", and the Sixth International Symposium on Ceramics in Medicine (1993). He has lectured around the world and serves or has served on the editorial board of more than ten scientific journals in the biomaterials, bioceramics, bioengineering, tissue engineering, orthopaedics and dental fields. He has been a member of the editorial board, and then an associate editor of Biomaterials, the leading biomaterials journal, since its inception in the late seventies. He has authored more than 300 papers and chapters in a variety of international journals and books, and he has edited 10 books. He has also been granted more than 40 US patents with international counterparts. His papers have been cited about 7000 times; his ten most visible papers have been cited more than 2000 times. Paul Ducheyne started his career in Europe. While at the K.U. Leuven, Belgium (1977 - 1983), he was one of the co-founders of the Post-Graduate Curriculum in Bioengineering. This program is now a full M.Sc. program in the School of Engineering and Applied Sciences. In those initial years, he was also chairman-founder of the chapter on Biomedical Engineering of the Belgian Engineering Society (Flemish section) and director of Meditek, the Flemish Government body created to promote Academia to Industry Technology Transfer in the area of Biomedical Engineering. Paul Ducheyne founded Gentis, Inc., which focuses on breakthrough concepts for spinal disorders. Previously, he founded Orthovita (NASDAQ: VITA) in 1992 and served as Chairman of its Board of Directors until 1999. Orthovita focuses on bioceramic implant materials for orthopaedics. Paul Ducheyne has been secretary of the European Society for Biomaterials, is Past President of the Society for Biomaterials (USA) and Past President of the International Society for Ceramics in Medicine. He has been recognized as a fellow of the American Association for the Advancement of Science (AAAS), fellow of the American Institute of Medical and Biological Engineering (AIMBE), and fellow of the International Association of Biomaterials Societies. He was the first Nanyang Visiting Professor at the Nanyang Institute of Technology, Singapore and he has received the C. William Hall Award from the Society for Biomaterials. Many of Paul Ducheyne's trainees have become leaders of the next generation. Among his trainees are professors at the University of California at Berkeley, the University of Michigan, Columbia University, Georgia Institute of Technology, the K.U. Leuven (Belgium), etc... Among the six U.S. Associate Editors of the Journal for Biomedical Materials Research (the Journal of the Society for Biomaterials), three were his PhD students.

      Affiliations and Expertise

      University of Pennsylvania, Philadelphia, PA, USA

      Kevin Healy

      Kevin E. Healy, Ph.D. is the Jan Fandrianto Distinguished Professor in Engineering at the University of California at Berkeley in the Departments of Bioengineering and Materials Science and Engineering. He received a Bachelor of Science degree from the University of Rochester in Chemical Engineering in 1983. In 1985 he received a Masters of Science degree in Bioengineering from the University of Pennsylvania, and in 1990 he received a Ph.D. in Bioengineering also from the University of Pennsylvania. He was elected a Fellow of the American Institute of Medical and Biological Engineering in 2001. He has authored or co-authored more than 200 published articles, abstracts, or book chapters which emphasize the relationship between materials and the tissues they contact. His research interests include the design and synthesis of biomimetic materials that actively direct the fate of embryonic and adult stem cells, and facilitate regeneration of damaged tissues and organs. Major discoveries from his laboratory have centered on the control of cell fate and tissue formation in contract with materials that are tunable in both their biological content and mechanical properties. These materials find applications in medicine, dentistry, and biotechnology. He is currently an Associate Editor of the Journal of Biomedical Materials Research. He has served on numerous panels and grant review study sections for N.I.H. He has given more than 200 invited lectures in the fields of Biomedical Engineering and Biomaterials. He is a named inventor on numerous issued United States and international patents relating to biomaterials, and has founded several companies to develop materials for applications in biotechnology and regenerative medicine.

      Affiliations and Expertise

      University of California, Berkeley, Berkeley, CA, USA

      Dietmar E. Hutmacher

      Professor Dietmar W. Hutmacher holds an accomplished international profile and strong research focus in the field of biomaterials, tissue engineering and regenerative medicine. Outcomes from Prof. Hutmacher's research have resulted in high profile scientific and academic contributions as well as patents and commercialization. He was named as one of the world's top materials scientist by Thomson Reuters in 2010 (ranked 45 out of the top 100). Prof. Hutmacher's track record shows that he has successfully mastered the main challenge in the biomedical sciences field, namely to cross traditional boundaries to nurture and initiate research and educational programs across different disciplines, particularly within engineering, biology and medicine.

      Affiliations and Expertise

      Queensland University of Technology, Brisbane, QLD, Australia

      David W. Grainger

      David W. Grainger is the George S. and Dolores Doré Eccles Presidential Endowed Chair in Pharmaceutics and Pharmaceutical Chemistry, Chair of the Department of Pharmaceutics and Pharmaceutical Chemistry, and Professor of Bioengineering at the University of Utah. Grainger received his Ph.D. in Pharmaceutical Chemistry from the University of Utah in 1987 studying blood-compatible polymers, particularly block copolymers functionalized with heparin blocks and their coatings. He then received an Alexander von Humboldt Fellowship to perform postdoctoral research under Prof. Helmut Ringsdorf, University of Mainz, Germany. This training initiated over 25 years of experience with various aspects of developing "materials in medicine". Grainger's research expertise is focused on improving implanted medical device performance, drug delivery of new therapeutic proteins, nucleic acids and live vaccines, nanomaterials interactions with human tissues, low-infection biomaterials, and innovating diagnostic devices based on DNA and protein biomarker capture. Additionally, he is an expert in applications of surface analytical methods to biomedical interfaces, including difficult surface patterns and nanomaterials, and perfluorinated biomaterials. Grainger has published over 130 full research papers at the interface of materials innovation in medicine and biotechnology, and novel surface chemistry. He has won research several awards, including the prestigious 2007 Clemson Award for Basic Research, Society for Biomaterials, and the 2005 American Pharmaceutical Research and Manufacturer's Association's award for "Excellence in Pharmaceutics". He won a short-term visiting professorship in Tokyo from the Japanese Society for the Promotion of Science, and a CNRS Visiting Professorship in Paris, France. He has also received several teaching awards for outstanding mentoring and teaching service, including the University of Utah 2010 Distinguished Postdoctoral and Graduate Student Mentoring Award, the US West/Qwest Faculty Education Excellence Award (Colorado State University, 2000), Colorado State University College of Natural Sciences "Undergraduate Teacher of the Year", 2000, Colorado State University Alumni Association "Teacher of the Year", 2002, and several "Favorite Faculty" Awards from CSU Undergraduate Student Associations. Grainger delivered the EU Madame Curie guest lectures at the Technical University-Aachen, Germany in 2009 and the 15th Annual Fritz Straumann lecture, AO Foundation, Davos, Switzerland, December, 2008. Grainger is an elected Fellow of both the American Association for the Advancement of Science (AAAS) and the American Institute of Medical and Biological Engineering (AIMBE), and Inducted Honorary Fellow, International Union of the Societies of Biomaterials Science and Engineering, 2008. He has organized 23 international scientific symposia including the prestigious Gordon Research Conference in Biomaterials, presented over 320 hundred invited talks all over the world. He serves on editorial boards for 4 major research journals in the biomedical materials field, reviewing over 50 manuscripts annually. He is Chair and standing member of Emerging Bioanalytical Technologies scientific review group (SRG) at NIH, past standing member on the NIH's Surgery and Bioengineering SRG, and over 20 other NIH and NSF review panels, some as chair. Additionally, he serves on the Scientific Advisory Boards of the Univ. Wisconsin-Madison NSF MRSEC on High Performance Nanostructured Materials, the NIH P41 National Research Center at the University of Washington (NESAC/Bio) for surface analysis for biomedical problems, NSF Harvard/New Mexico NSF PREM MRSEC, and several international research foundations (AO Foundation, Davos, Switzerland, Swiss Center for Materials Competence, Zurich, the Willem S. Kolff Institute, Royal University

      Affiliations and Expertise

      University of Utah, Salt Lake City, UT, USA

      C. James Kirkpatrick

      C. James Kirkpatrick is currently Professor of Pathology and Chairman of the Institute of Pathology at the Johannes Gutenberg University of Mainz, Germany, having taken up this position in 1993. He is also Honorary Professor at both the Peking Union Medical College, Beijing and the Sichuan University, Chengdu in China. Kirkpatrick is a graduate of the Queen's University of Belfast and holds a triple doctorate in science and medicine (PhD: 1977; MD: 1982; DSc: 1992). Previous appointments were in pathology at the University of Ulm, where he did post-doctoral research in experimental pathology, Manchester University (Lecturer in Histopathology) and the RWTH Aachen (Professor of Pathology & Electron Microscopy). On moving to Aachen in 1987 he established a cell culture laboratory which began using modern methods of cell and molecular biology to study how human cells react to biomaterials. Since then his principal research interests continue to be in the field of biomaterials in tissue engineering and regenerative medicine, with special focus on the development of human cell culture techniques, including novel 3D coculture methodology for biomaterials. His research laboratory, the REPAIR-lab, is a member of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, and his research is principally funded by the EU, BMBF (German Federal Ministry of Education and Research), BMVg (German Federal Ministry of Defence) and the DFG (German Research Foundation). This emphasis on developing sophisticated in vitro techniques has brought him the Research Prize of the State of Rhineland-Palatinate for Research on Replacement and Alternative Methods for Animal Research. In 2010 he received, as first medical graduate, the Chapman Medal from the Institute of Materials, Minerals & Mining in London for "distinguished research in the field of biomedical materials". He is author/coauthor of more than 380 publications in peer-reviewed journals and has made more than 1000 presentations to scientific meetings worldwide. He is a former President of both the German Society for Biomaterials (2001-2005) and the European Society for Biomaterials (2002-2007; George Winter Award 2008) and has served on the Council of the latter since 1995. Kirkpatrick is a long-standing member of the Editorial Board of the premier journal Biomaterials and is a current Associate Editor (since 2002). He has also served as Associate Editor of the leading Journal of Pathology (2001-2006). In total, he serves or has served as an Editorial Board member of 18 international journals in pathology, biomaterials and tissue engineering. Kirkpatrick is a member of the Scientific Advisory Board of a number of research institutes, centres of excellence and companies in biomaterials and regenerative medicine in Europe, as well as the Medical Technology Committee, Federal Ministry of Education & Research in Germany (BMBF) (since 2005) and the German Federal Institute for Drugs & Medical Devices (BfArM)(since 2007). During his entire research career, Kirkpatrick has actively practiced diagnostic histopathology, which has allowed him to apply modern molecular pathology techniques to the study of biofunctionality of biomaterials. Since 1997 he is a Fellow of the Royal College of Pathologists, London and since 1995 a Fellow of Biomaterials Science & Engineering (FBSE) of the IUS-BSE (International Union of Societies for Biomaterials Science & Engineering). He is also in a second term of service on the Council of the European Chapter of the Tissue Engineering & Regenerative Medicine International Society (TERMIS-EU). Kirkpatrick had also had the privilege of chairing the Scientific Programme Committee for the 8th World Biomaterials Congress in Amsterdam in 2008.

      Affiliations and Expertise

      Johannes Gutenburg University Medical Center, Mainz, Germany

      Comprehensive Biomaterials, 1st Edition

      The concept of Biocompatibility
      Biocompatibility and the relationship to standards; meaning and scope of biocompatibility testing
      Biomaterials and the innate response
      Adaptive immune responses to biomaterials
      Leukocyte-biomaterial interactions in vitro
      Protein interactions with biomaterials
      Bacterial adhesion and biomaterial surfaces
      Anti-inflammatory properties of metals
      Integrin activated reactions to metallic implant surfaces
      Nanostructured surfaces and cell behaviour
      Nanoparticles and biocompatibility
      Sterilization of biomaterials of synthetic and biological origin
      "Metals for use in medicine
      Electrochemical behavior of metals in biological milieus
      Shape memory alloys for use in medicine
      Carbons, carbon films and diamond
      Ceramic films
      Bioactive Ceramics
      Bioactive glass ceramics
      Bioactive Ceramics – physical chemistry
      Calcium phosphate coatings
      Bioactive layer formation on metals and polymers
      Bioactivity – mechanisms
      Bioceramics and gene therapy
      Bioactive ceramics – cements
      Composite bioactive ceramics – polymers
      Phosphate glasses
      Copper doping of calcium phosphate ceramics
      Silicon containing apatites
      Polymer Fundamentals: Polymer Synthesis
      Structural Biomedical Polymers (Non-degradable)
       Degradable polymers
      Polymers at Surfaces
       Polyurethanes and Silicone Polyurethane Copolymers
      Carbohydrate Polymers
       Shape-Memory Polymers
      Electrospinning and Polymer Nanofibers: I Process Fundamentals
      Stimuli-responsive hydrogels
      Electroactive Polymeric Biomaterials
      Superporous hydrogels for drug delivery systems
      Dynamic Hydrogels
      Carbon Nanotube and fullerenes materials
      Nanostructures, topography, block copolymers
      Nanoscale Chemistry for Cell Biology
      Bioinspired Adhesives
      Biomineralization and New Materials
      Engineered Viruses for Gene Therapy
        Artificial and Natural Protein Polymers – Synthesis and Characterization
       Peptoids – Synthesis, Characterization, and Nanostructures
      Self-Assembling Biomaterials
      Virotronics: Phage viruses as developmental tools for functional nanomaterials
      Extracellular matrix-like biomaterials
      Artificial extracellular matrices to functionalize biomaterials surfaces
      Materials for artificial stem cell microenvironments
      Molecularly Imprinted Polymers
      Advanced biophysical methods of analysis
      Bone as a material
      "Materials of Biological origin – Overview
      Elastin Biopolymers
      Hyaluronic Acid
      Collagen-GAG Materials
      Extracellular matrix as a biomimetic biomaterial  - Biological matrices for tissue regeneration
      Decellularized scaffolds
      "Xenogeneic tissues for the skeletal system
      Bacterial cellulose
      Surface Analysis and Biointerfaces:  UHV and In Situ Techniques
      Atomic Force Microscopy
       Proteomic and Advanced Biochemical Techniques to Study Protein Adsorption
      New developments in Synchroton-CT
      Fracture mechanics of ceramics as related to bioceramics use
      Thin  films – mechanical properties
      Finite element analysis – bone tissue
      Cardiac Mechanics
      Fluid Mechanics - Transport and diffusion analyses as applied in biomaterials studies
      Computational methods related to reaction chemistry
      Molecular Simulation Methods to Investigate Protein Adsorption Behavior at the Atomic Level
      Cell culture systems for biomaterial delivery across biological barriers
      Histological analysis
       Fluorescence Imaging of cell-biomaterial interactions
       Molecular Imaging
       Microarrays in biomaterials research
       Gene expression and quantitative PCR
       Infrared and Raman microscopy
       Magnetic Resonance of Bone Micro- and Nanostructure
       Nanoparticles for biological imaging
       Imaging techniques for mineralization
       Imaging and diagnosis of biological markers
       Materials to Control and Measure Cell Function
       BioMEMS devices
       Intracellular Sensing
       Biosensors based on sol-gel derived materials
       Hydrogel based sensors
       Carbon Nanotube-based Sensor: Overview
       Conjugated polymers for biosensor devices
       Implantable continuous glucose sensors
       Engineering surfaces
       Peptide and Protein Modified Surfaces
       Combinatorial methods to create designer protein interfaces
       Non-fouling Interfaces
       Patterned Biointerfaces
       Molecular Biomimetic Designs for Controlling Surface Interactions
       Surface Engineering using Peptide Amphiphiles
       Growth Factor and Protein Modified Surfaces and Interfaces
       Tethered antibiotics
       Engineering Interfaces for Infection Immunity
       Design Principles in Biomaterials and Scaffolds
       vaccine/immunotherapy delivery
       Nanoparticles for Nucleic Acid Delivery
       Synthetic “Smart” Polymeric Carriers for Intracellular Delivery
       Self-Assembled Prodrugs
       Delivery by Heparin conjugation
       Bioinspired pH-Responsive Polymers for the Intracellular Delivery of Biomolecular Drugs
       Polymeric drugs
       Sol gel processed oxide controlled release systems - Overview
       Mesoporous silica materials
       Encapsulation of Cells (Cellular delivery) using sol-gel systems
       Layered double hydroxides as controlled release materials
       Porous Metal – organic – frameworks as new drug carriers
       Hybrid nanoparticles for targeted delivery
      Silica based nanospheres
       Gene delivery
       Nanofiber for drug delivery
       Cell-demanded Delivery of Growth Factors
       Scaffolds – Flow Perfusion - Bioreactor design
       Engineering Scaffold Mechanical and Mass Transport Properties
       Bioactive ceramics and bioactive ceramic composite based scaffolds
       Scaffolds and angiogenesis
       Effect of material modulus on cell function and differentiation
       Quantifying Integrin-Ligand Engagement and Cell Phenotype in 3D scaffolds
       Effect of mechanical stress on cells
       Tissue engineering and selection of growth factors and cytokines
       Tissue engineering and selection of cells
       Scaffold materials for hES Cell Culture and Differentiation
       Cell encapsulation
       Engineered bioactive molecules
       Rotating wall vessels for cell culture
       In vivo Bioreactors
       Bone Tissue Engineering Concepts
       Calcium phosphate and bone induction
       Tissue Engineering Treatments in Oral, Maxillofacial and Cranial Surgery
       Tissue  Engineering of the Temporo Mandibular Joint
       Autologous, vascularized bone grafts
       (Tissue Engineering of) Synovial Joints and Articular Cartilage
       tentative title
       Chondrocyte transplantation and selection
       Tissue Engineering of Meniscus and Annulus Fibrosus
       Tissue Engineering Approaches to Regeneration of Anterior Cruciate Ligament
       Tissue Engineering of muscle tissue
       Vascular Tissue Engineering
       Tissue Engineering of Heart Valves
       Materials for Cardiac Cell Transplantation
       Cell sheet engineering
       Peripheral nerve regeneration
       Nerve tissue engineering
       Biomaterials for central nervous system regeneration
       Skin Tissue Engineering
       Fibrocartilage regeneration
       Tissue Engineering hollow non-cardiac intrathoracic oragans: stage-of-the-art 2010
       Adipose tissue engineering
       From tissue to organ engineering
       Kidney tissue engineering
       Liver Tissue Engineering
       Organ printing
       Systems Biology and the relationship to Biomaterials/ Tissue Engineering
       Intervertebral disc
       Current and projected use of joint prostheses
       Bone Cement
      " Ceramic joint prostheses – clinical results – worldwide
       Porous Coatings in Orthopaedics
       Wear - Hip joint arthroplasty
       Wear – Knee joint arthroplasty
       Effect of wear particulates
       Fretting Corrosion
       Metallic dissolution product - Clinical data, relevance
       Trends in materials for spine surgery
       Injectable bone cements for spinal column augmentation  - Materials for kyphoplasty / vertebroplasty
       Biomaterials for intervertebral disc regeneration
       Nucleus Replacements
       Wear - Total intervertebral disc prostheses
       Experimental studies in spinal fusion
       Materials in fracture fixation
       Synthetic bone grafts
       Cellular Selection for Bone Tissue Grafting
       Implant use and infection
       Materials in Tendon and Ligament Repair
       Materials for use in Oral & Maxillofacial Surgery
       Materials in Dental Implantology
       Implant Surface Roughness
       Materials in prosthodontics: fillings, crowns, bridges
       Dental Graft Materials – all (light on in situ excavated glass granules)
       Cardiac patch (with cells, biological or synthetic)
       LVAD/Artificial Heart
       Cardiac Valves: Biologic and Synthetic
       Intravasular Stents: History, overview
       Drug Eluting Stents
       Biodegradable Stents
       Vascular Grafts
       Cerebrospinal fluid shunts
       Biomaterials for spinal cord repair
       Corneal Reconstruction with Cell Sheets
       Artificial Cornea (Keratoprosthesis)
       Retina Reconstruction
       Development of Contact Lenses from a Biomaterial Point of View - State of the Art and Future Perspectives
       Artificial Kidney
       Surgical Adhesion and its prevention
       Suture materials – conventional and stimuli-responsive
       Reinforcement of staple lines with buttressing materials
       Biomaterials for hernia repair

      Quotes and reviews

      "In a highly technical and vastly broad subject area, the key to managing (mastering) reputable information and facilitating new breakthroughs is through its preservation and organization by experts in the field. For students or researchers wanting a quick introduction or a working knowledge of an unfamiliar subfield of biomaterials, the assembled chapters will be much more valuable than the typical documents that rise to the top of keyword searches. The authors and editors should be commended for their efforts and congratulated on producing an impressive reference of lasting value. In this reviewer's opinion, it will be an essential reference for any library affiliated with graduate programs in the biomedical sciences. Summing Up: Highly recommended. Upper-division undergraduates and above."--CHOICE

      "[T]his is a huge body of work and I would suspect the price would preclude individual researchers from acquiring the set; however, this is a must have for libraries as an up-to-date reference for the current state-of–the-art information in this field as well as a fundamental reference tome for researchers seeking an introduction to the field."--Journal of Biomaterials Applications, Vol. 26, February 2012, page 761


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