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Adult Neurogenesis in the Hippocampus
Health, Psychopathology, and Brain Disease
1st Edition - March 23, 2016
Editor: Juan J. Canales
Language: English
Hardback ISBN:9780128019771
9 7 8 - 0 - 1 2 - 8 0 1 9 7 7 - 1
eBook ISBN:9780128019924
9 7 8 - 0 - 1 2 - 8 0 1 9 9 2 - 4
Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health…Read more
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Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease.
Provides a unique overview of how adult hippocampal neurogenesis contributes to adaptive processes, brain psychopathology, and disease
Includes state-of-the-art reviews by leading world experts in adult neurogenesis
researchers and advanced graduate students in behavioral neuroscience, cognitive neuroscience, neurobiology, translational neuroscience, and neuropsychology, as well as cognitive and behavioral psychology, clinical psychology, and psychiatry
Dedication
List of Contributors
Preface
I. Neurobiology and Physiology of Hippocampal Neurogenesis
Chapter 1. Neurobiology
Introduction
Neurogenesis Takes Place in the Dentate Gyrus of the Hippocampus
Neurogenesis in Rodents
Neurogenesis in Primates
Conclusions
Chapter 2. Physiology and Plasticity
Introduction
The Generation and Development of Adult-Born Dentate Granule Cells
Adult-Born Dentate Granule Cells Regulate Structural and Physiological Plasticity of the Dentate Gyrus
The Function of Adult-Born Dentate Granule Cells in Circuits and Behavior
Conclusions
Chapter 3. Cellular and Molecular Regulation
Introduction
Cellular identity of adult hippocampal neural stem/progenitor cells
Mechanisms of stem cell activation and proliferation
Mechanisms of neuronal fate determination
Mechanisms of neuronal maturation and functional integration
Conclusions
II. Neurogenesis in Health and Well-Being
Chapter 4. Learning and Memory
Introduction
Adult Neurogenesis Across Life Span
Evidence for Cognitive Reserve
The Neurogenic Reserve Hypothesis
Presence of Early Neurogenic Changes in Alzheimer’s Disease Mouse Models
Neuropathology: Not the Complete Picture
Pattern Separation, Neurogenesis, and Alzheimer’s Disease
Conclusions
Chapter 5. Physical Exercise
Introduction
Voluntary Wheel Running
Forced Exercise
The Effect of Age on Exercise-Induced Hippocampal Neurogenesis
Sex Differences in Exercise-Induced Enhancements in Hippocampal Neurogenesis
Cellular Mechanisms
Measuring Hippocampal Neurogenesis in the Human Brain
Exercise Improves Cognitive Function in Humans
Conclusions
Chapter 6. Dietary and Nutritional Regulation
Introduction
Dietary Regulation of Adult Hippocampal Neurogenesis
Nutritional Supplementation
Human Studies
Translational Considerations: from Animals to Humans
Conclusions
Chapter 7. Aging
Introduction
Aging and Neurogenesis
Neurogenesis and Cognition in Aging
III. Neurogenesis in Psychopathology and Disease
Chapter 8. Adult Neurogenesis, Chronic Stress and Depression
Introduction
Stress-Related Changes in Major Depression
Structural Plasticity and Adult Neurogenesis
Stress Regulation of Neurogenesis
Neurogenesis and Major Depression
Conclusions
Chapter 9. Acute Stress and Anxiety
Introduction
Does Hippocampal Neurogenesis Impact on Anxiety Behavior?
Does Acute Stress Impact on Neurogenesis?
Conclusions
Chapter 10. Addiction
Introduction
Role of the Hippocampus in Addictive Behavior
Toxic Effects of Drugs on Adult Hippocampal Neurogenesis
Neurogenesis, Cognition, and Persistent Drug Seeking
Conclusions
Chapter 11. Neurological Disorders
Introduction
Neurodegenerative Diseases
Neurodevelopmental Disorders
Neurogenesis and Brain Injury
Conclusions
List of Abbreviations
Index
No. of pages: 298
Language: English
Edition: 1
Published: March 23, 2016
Imprint: Academic Press
Hardback ISBN: 9780128019771
eBook ISBN: 9780128019924
JC
Juan J. Canales
Dr. Juan J. Canales is a Reader in Behavioural Neuroscience in the Department of Neuroscience, Psychology and Behaviour at the University of Leicester (United Kingdom). Dr. Canales obtained his doctorate at the University of Oxford and after postdoctoral placements at the Massachusetts Institute of Technology (Cambridge, USA) and the Valencia Foundation for Biomedical Research (Spain), he became Ramon y Cajal Senior Scientist and later Institute Investigator at the University of Valencia (Spain). Before joining the University of Leicester, Dr. Canales was a Senior Lecturer in the Department of Psychology at the University of Canterbury (New Zealand). His research focuses on the neuropharmacology of drug addiction, the discovery of new targets for therapeutic intervention in addiction, and the involvement of postnatal neurogenesis in health and psychopathology.
Affiliations and expertise
Senior Lecturer, Department of Psychology, University of Canterbury, New Zealand
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